| 外泌体与缺血性脑卒中及针灸干预机制 |
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| 引用本文： | 李巧凤,彭拥军,李忠仁,洪浩,储继红,蔡云.外泌体与缺血性脑卒中及针灸干预机制[J].世界科学技术-中医药现代化,2020,22(1):183-188. |
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| 作者姓名： | 李巧凤 彭拥军 李忠仁 洪浩 储继红 蔡云 |
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| 作者单位： | 南京中医药大学附属医院 南京210029;南京中医药大学 南京210029 |
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| 基金项目： | 国家自然科学基金委员会面上项目（81973932）：基于外泌体miR-210介导的HIF-1/VEGF/Notch信号通路探讨电针促进脑缺血后血管新生的机制研究,负责人：彭拥军;国家自然科学基金委员会面上项目(81574060):电针通过介导组蛋白H4K16乙酰化表观遗传修饰调控细胞自噬减轻脑缺血再灌注损伤的机制研究,负责人：彭拥军;国家自然科学基金委员会青年科学基金项目(81001556)：AQP4在电针抗脑缺血再灌注后血脑屏障损伤中的作用研究,负责人：彭拥军。 |
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| 摘 要： | 近年来的研究发现一些特异性治疗性外泌体可作为缺血性脑卒中（ischemic stroke,IS）治疗的新靶点,本文旨在研究外泌体作为细胞间通讯新介质对于IS的诊断及对于受损脑组织的保护作用,讨论外泌体中微小核糖核酸（microRNAs,miRNA）作为缺血性中风的新兴生物标志物和治疗靶标的潜在临床应用。进一步探讨针灸对外泌体的影响,外泌体对针灸刺激的应答作用,为阐述针灸治疗IS的机制提供新思路,为发挥针灸治疗优势提供科学依据。
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| 关 键 词： | 外泌体 针灸 缺血性脑卒中 |
| 收稿时间： | 2019/3/5 0:00:00 |
| 修稿时间： | 2020/2/26 0:00:00 |
Exosomes and Ischemic Stroke and Acupuncture Intervention Mechanism |
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| Li Qiaofeng,Peng Yongjun,Li Zhongren,Hong Hao,Chu Jihong and Cai Yun.Exosomes and Ischemic Stroke and Acupuncture Intervention Mechanism[J].World Science and Technology-Modernization of Traditional Chinese Medicine,2020,22(1):183-188. |
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| Authors: | Li Qiaofeng Peng Yongjun Li Zhongren Hong Hao Chu Jihong and Cai Yun |
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| Institution: | The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China,The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China,Nanjing University of Chinese Medicine, Nanjing 210029, China,Nanjing University of Chinese Medicine, Nanjing 210029, China,The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, China,Nanjing University of Chinese Medicine, Nanjing 210029, China |
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| Abstract: | Recently, some studies have found that many specific therapeutic exosomes can be used as new targets for the treatment of ischemic stroke (IS). The purpose of this study was to investigate the role of exosomes as a new intercellular communication medium in the diagnosis of IS and its protective effect on damaged brain tissue, and to discuss the potential clinical application of miRNA in exosomes as emerging biomarkers and therapeutic targets for IS. To further explore the effect of acupuncture and moxibustion on exosomes and their response to acupuncture and moxibustion stimulation, so as to provide new ideas for the mechanism of acupuncture and moxibustion in the treatment of IS and provide scientific basis for giving play to the advantages of acupuncture and moxibustion. |
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| Keywords: | Exosomes Acupuncture Ischemic stroke |
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