基于多指标综合评分法优选化胃舒颗粒挥发油包合工艺

目的优选化胃舒颗粒中β-环糊精包合挥发油的最佳工艺。方法以挥发油与β-环糊精比例、包合温度、搅拌速度、搅拌时间为考察因素,采用正交试验对包合工艺条件进行优选,通过熵权法确定各指标的权重系数,采用薄层色谱法对包合物进行验证。结果搅拌法得到的挥发油包合率最高,β-环糊精与挥发油比例10∶1,包合温度40℃,搅拌时间1 h,搅拌速率400 r/min。结论优选的挥发油包合工艺稳定可行、挥发油包合率和包合物收率高。

Optimization of inclusion process of Huaweishu Granules volatile oil based on the multi-index comprehensive scoring method

Objective To optimize the inclusion process for the volatile oil in Huaweishu Granules. Methods Taking the ratio of volatile oil to β-cyclodextrin, inclusion temperature, stirring speed and stirring time as the factors, the inclusion process conditions were optimized by orthogonal test, the weight coefficients of each index were determined by entropy weight method, and the inclusion complex was verified by thin layer chromatography. Results The inclusion rate of volatile oil obtained by stirring method was the highest, with the ratio of β-cyclodextrin to volatile oil of 10∶1, the inclusion temperature was 40 ℃, the stirring time was 1 h, and the stirring rate was 400 r/min. Conclusion The optimized volatile oil inclusion process is stable and feasible, with high inclusion rate of volatile oil and yield of inclusion compound.