| 白芍方药以及白芍总苷镇痛功效及其机理研究进展 |
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| 引用本文： | 代倩倩,夏欢,夏桂阳,商洪才,石兆峰,黄雨丝,李心怡,林生,田贵华. 白芍方药以及白芍总苷镇痛功效及其机理研究进展[J]. 世界科学技术-中医药现代化, 2020, 22(1): 39-46 |
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| 作者姓名： | 代倩倩 夏欢 夏桂阳 商洪才 石兆峰 黄雨丝 李心怡 林生 田贵华 |
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| 作者单位： | 北京中医药大学东直门医院中医内科学教育部和北京市重点实验室 北京100700 |
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| 基金项目： | 北京中医药大学东直门医院2018青苗人才计划（DZMYS-201801）,负责人：田贵华;国家自然科学基金面上项目（81674050）：电针对CPSP大鼠星形胶质细胞介导的Wnt/β-catenin信号通路调控作用,负责人：田贵华。 |
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| 摘 要： | 目的 综述古籍中对白芍镇痛功效的记载,以及近年来阐述白芍镇痛功效与机理的研究,为其临床应用和效应机制的深入研究提供参考依据。方法 查阅古籍和近年有关白芍镇痛功效的文献报道,并进行归纳、分析和总结。结果 历代诸多医家及著作均有对白芍镇痛功效与主治的详细描述。临床研究证实白芍方药及其提取物白芍总苷对于腰腿痛、内脏痛、头痛、癌性疼痛等痛证疗效确切,副作用少。基础实验表明,白芍及其提取物可通过调节前列腺素、相关受体和信号转导通路等多种途径发挥镇痛作用,还可拮抗吗啡等西药镇痛耐受,与甘草、川乌、马钱子等中药配伍后,还具有一定的增效减毒作用。结论 白芍在治疗多种痛证方面疗效显著,机制复杂,具有很好的发展潜力和很高的研究价值,有待进一步探索发掘。
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| 关 键 词： | 白芍 白芍总苷 镇痛功效 镇痛机理 研究进展 |
| 收稿时间： | 2020-02-10 |
| 修稿时间： | 2020-03-12 |
Research Progress on Analgesic Effect and Mechanism of Radix Paeoniae Alba Decotion and Total Glucosides of Paeony |
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| Dai Qianqian,Shang Hongcai,Lin Sheng,Shi Zhaofeng,Huang Yusi,Li Xinyi and Tian Guihua. Research Progress on Analgesic Effect and Mechanism of Radix Paeoniae Alba Decotion and Total Glucosides of Paeony[J]. World Science and Technology—Modernization of Traditional Chinese Medicine and Materia Medica, 2020, 22(1): 39-46 |
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| Authors: | Dai Qianqian Shang Hongcai Lin Sheng Shi Zhaofeng Huang Yusi Li Xinyi Tian Guihua |
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| Affiliation: | Key Laboratory of Chinese Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Key Laboratory of Chinese Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Key Laboratory of Chinese Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Key Laboratory of Chinese Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Key Laboratory of Chinese Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Key Laboratory of Chinese Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine,Key Laboratory of Chinese Medicine of Ministry of Education and Beijing Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine |
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| Abstract: | |
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| Keywords: | Radix paeoniae alba total glucosides of paeony analgesic effect analgesic mechanism research progress |
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