18F-氟脱氧葡萄糖PET在原发性肝细胞癌中的应用

肝细胞癌(HCC)的早期诊断是获得临床治愈的关键,准确分期是制定合理治疗方案的基础.尽管18F-氟脱氧葡萄糖(18F-FDG)PET诊断HCC的总体敏感性不高,但其阳性显像与肿瘤分化程度、肝内外转移、门静脉癌栓及血清甲胎蛋白水平等许多因素相关.因此,18F-FDG PET在中、低分化的HCC诊断、分期与再分期、监测治疗反应、评价疗效、判断预后以及鉴别肝脏良性疾病等方面具有独特的价值.

Application of positron emission tomography with 18F-fluorodeoxyglucose in hepatocellular carcinoma

Early diagnosis of hepatocellular carcinoma(HCC)is the key point for clinic heMing,and accurate staging is the foundation of rational therapy.Positron emission tomography with 18F-fluorodeoxyglucose (18F-FDG)PET isn't sufficiently sensitive on detecting HCC,but the positive imaging is related on many factom such as malignant degree,intra/extrahepatic metastases,tumor thrombus in a portal vein,the level of alpha-fetoprotein in blood serum and so on.Thus,18F-FDG PET has a special value on moderatelv or poody differentiated HCC for differential diagnosing,staging and restaging,monitoring responses to treatments,evaluating therapeutic effects,and predicting the prognosis.