| 5-HTTLPR基因多态性与原发性早泄关系研究进展 |
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| 引用本文： | 郭军,韩强,张修举,王福,高庆和,张继伟,曾银,邱俊峰.5-HTTLPR基因多态性与原发性早泄关系研究进展[J].中国性科学,2017(2):8-9. |
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| 作者姓名： | 郭军 韩强 张修举 王福 高庆和 张继伟 曾银 邱俊峰 |
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| 作者单位： | 1. 中国中医科学院西苑医院男科,北京,100091;2. 首都医科大学附属北京中医医院男科,北京,100010 |
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| 基金项目： | 国家自然科学基金资助项目(81273930) |
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| 摘 要： | 早泄(PE)是一种常见的男性性功能障碍,目前的研究尚未能揭示所有PE患者的病因,因此进一步阐明PE发病机制以改善PE治疗思路具有重要意义。近年的研究热点显示PE还受遗传因素的影响,PE发病与基因多态性之间的相关性受到了重视,并主要集中在5-羟色胺(5-HT)相关基因研究上。本文旨在综述原发性PE相关5-HT转运体基因启动子区(5-HTTLPR)基因多态性方面的发病机制的研究进展。
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| 关 键 词： | 早泄 5-HTTLPR基因 基因多态性 |
Research on relations between primary premature ejaculation and serotonin transporter promoter gene polymorphism |
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| GUO Jun,HAN Qiang,ZHANG Xiuju,WANG Fu,GAO Qinghe,ZHANG Jiwei,ZENG Yin,QIU Junfeng.Research on relations between primary premature ejaculation and serotonin transporter promoter gene polymorphism[J].The Chinese Journal of Human Sexuality,2017(2):8-9. |
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| Authors: | GUO Jun HAN Qiang ZHANG Xiuju WANG Fu GAO Qinghe ZHANG Jiwei ZENG Yin QIU Junfeng |
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| Abstract: | Premature ejaculation (PE) is a common male sexual dysfunction,the cause of which remains mostly unclear.It is therefore of significant importance to further explain the mechanism of the disorder as well as widen the scope of therapy ideas through more in-depth research.Recent research has shown that the onset PE may be influenced by hereditary factors,and there is a significant relationship between onset of the disorder and gene polymorphism,more specifically,genes related to the production and management of 5-hydroxytryptamine (5-HT).This article aims to provide an overview of the research and development on primary premature ejaculation in relations to serotonin transporter promoter gene polymorphism and its onset mechanism. |
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| Keywords: | Premature ejaculation (PE) Serotonin transporter promoter Gene polymorphism |
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