Effect of glial cells on remyelination after spinal cord injury |
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| Authors: | Hai-feng Wang Xing-kai Liu Rui Li Ping Zhang Ze Chu Chun-li Wang Hua-rui Liu Jun Qi Guo-yue Lv Guang-yi Wang Bin Liu Yan Li Yuan-yi Wang |
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| Institution: | 1. Department of Neurosurgery, First Hospital of Jilin University, Changchun, Jilin Province, China;2. Department of Hepatobiliary and Pancreas Surgery, First Hospital of Jilin University, Changchun, Jilin Province, China;3. Hand & Foot Surgery and Reparative & Reconstruction Surgery Center, Second Hospital of Jilin University, Changchun, Jilin Province, China;4. Department of Emergency, First Hospital of Jilin University, Changchun, Jilin Province, China;5. Department of Cardiology, First Hospital of Jilin University, Changchun, Jilin Province, China;6. Department of Surgery, School of Medicine, University of Louisville, Louisville, KY, USA;7. Department of Orthopedics, First Hospital of Jilin University, Changchun, Jilin Province, China |
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| Abstract: | Remyelination plays a key role in functional recovery of axons after spinal cord injury. Glial cells are the most abundant cells in the central nervous system. When spinal cord injury occurs, many glial cells at the lesion site are immediately activated, and different cells differentially affect inflammatory reactions after injury. In this review, we aim to discuss the core role of oligodendrocyte precursor cells and crosstalk with the rest of glia and their subcategories in the remyelination process. Activated astrocytes influence prolif-eration, differentiation, and maturation of oligodendrocyte precursor cells, while activated microglia alter remyelination by regulating the inflammatory reaction after spinal cord injury. Understanding the interac-tion between oligodendrocyte precursor cells and the rest of glia is necessary when designing a therapeutic plan of remyelination after spinal cord injury. |
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| Keywords: | nerve regeneration spinal cord injury remyelination oligodendrocyte precursor cells astrocytes oligodendrocytes microglia glial scar demyelination myelin central nervous system neural regeneration |
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