Solubility enhancement and physicochemical characterization of carvedilol solid dispersion with Gelucire 50/13 |
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| Authors: | Raja Hemanth Kumar Potluri Suresh Bandari Raju Jukanti Prabhakar Reddy Veerareddy |
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| Institution: | (1) Department of Pharmaceutical Technology, Institute of Pharmacy, Nirma University of Science & Technology, Ahmedabad, Gujarat, India;(2) Department of Pharmaceutics, PES College of Pharmacy, Bangalore, Karnataka, India;(3) Department of Pharmaceutics, The University of Mississippi, University, MS 38677, USA;(4) Department of Pharmaceutics, Arihant School of Pharmacy & Bioresearch Institute, Ahmedabad, Gujarat, India |
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| Abstract: | The objective of the study was enhancement of dissolution of poorly soluble carvedilol by solid dispersions (SDs) with Gelucire
50/13 using solvent evaporation method. The solubility of carvedilol showed linear increase with increasing concentrations
of Gelucire indicating AL type solubility diagrams. SDs characterized for physicochemical characteristics using differential scanning calorimetry and
X-ray diffractometry revealed transformation of crystalline form of drug to amorphous form which was confirmed by scanning
electron micrographs. Further fourier transform infrared spectroscopy results suggested there is no drug carrier interaction.
From the dissolution parameters such as mean dissolution time, dissolution efficiency and drug release rate, improved dissolution
characteristics for SDs were observed compared with physical mixture and pure drug. Thus SDs of carvedilol in Gelucire 50/13
showed enhanced solubility and dissolution rate compared to pure drug. |
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