| 凋亡相关基因蛋白bcl-2、fas在大肠息肉和肠癌中的表达 |
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| 引用本文： | 赵秀芳,薄爱华,何玉然,张晓丽,白丽娜.凋亡相关基因蛋白bcl-2、fas在大肠息肉和肠癌中的表达[J].现代肿瘤医学,2005,13(4):488-490. |
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| 作者姓名： | 赵秀芳 薄爱华 何玉然 张晓丽 白丽娜 |
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| 作者单位： | 1. 张家口市第六医院,河北,张家口,075000
2. 河北北方学院,河北,张家口,075000 |
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| 摘 要： | 目的探讨大肠息肉和大肠癌中凋亡相关基因bcl-2和fas表达状况。方法收集大肠炎活检标本30例,腺瘤样息肉28例,大肠腺癌78例;利用SP免疫组织化学方法,检测bcl-2、fas阳性率。结果bcl-2阳性率高于fas;大肠息肉和大肠癌中bcl-2和fas阳性率高于炎症粘膜组织(P<0.05);息肉与癌两组间差异无显著性(P>0.05)。结论粘膜炎症bcl-2和fas很少表达,在息肉和肠癌中表达增多,提示bcl-2和fas参与大肠癌形成过程。
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| 关 键 词： | 炎症 腺瘤样息肉 大肠癌 免疫组织化学 凋亡相关基因 bd-2 fas |
| 文章编号： | 1672-4992(2005)04-488-03 |
| 修稿时间： | 2004年12月22 |
Expression of proapoptosis gene bcl-2 and fas in carcinoma and polyp of large bowel |
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| ZHAO Xiu-fang,BO Ai-hua,HE Yu-ran,et al..Expression of proapoptosis gene bcl-2 and fas in carcinoma and polyp of large bowel[J].Journal of Modern Oncology,2005,13(4):488-490. |
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| Authors: | ZHAO Xiu-fang BO Ai-hua HE Yu-ran |
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| Institution: | ZHAO Xiu-fang,BO Ai-hua,HE Yu-ran,et al. Department of Pathology,The 6nd Hospital,Zhang Jia Kou 075000,China. |
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| Abstract: | Objective To study the expression of proapoptosis gene bcl-2 and fas in colorectal carcinoma and polyp. Methods S-P immunohistochemistry methods were used to defect the expression of bcl-2 and fas in 30 cases of enteritis,28 cases adenomatous polyp and 78 cases of adenocarcinoma. Results The positive rate of bcl-2 was higher than fas.The positive rate of bcl-2 and fas protein were significant higher in polyp and adenocarcinoma than enteritis (P< 0.05).There was no difference in the expression of the two groups between the above polyp and carcinoma (P> 0.05). Conclusion Both the bcl-2 and fas there was low expression in mucosa inflammation.Over-experssion of bcl-2 and fas in polyp and adenocareinoma.The result showed that bcl-2 and fas may play an role in the oncogenesis of large bowed. |
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| Keywords: | inflammation adenomatous adenocarcinoma immunohistochemistry proapoptosis gene bcl-2 fas |
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