| 蛋黄油为主复方制剂治疗大鼠放射性直肠炎 |
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| 引用本文： | 敖睿,孙岚,涂玲俐,卢铀. 蛋黄油为主复方制剂治疗大鼠放射性直肠炎[J]. 四川医学, 2011, 32(2): 148-150 |
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| 作者姓名： | 敖睿 孙岚 涂玲俐 卢铀 |
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| 作者单位： | 1. 四川大学华西临床医学院胸部肿瘤科,四川,成都,610041;四川省人民医院肿瘤科,四川,成都,610072
2. 四川大学华西临床医学院胸部肿瘤科,四川,成都,610041 |
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| 摘 要： | 目的观察以蛋黄油为主的复方制剂灌肠治疗SD大鼠放射性直肠炎的疗效。方法 24只SD大鼠随机分为4组：未放疗＋NS灌肠组（1组）;放疗＋生理盐水灌肠组（2组）;放疗＋蛋黄油灌肠组（3组）;放疗＋复方制剂灌肠组（4组）。除l组外所有大鼠盆腔均接受16.5gy剂量的放疗。大鼠自放疗开始后每天药物灌肠1次,10d后处死大鼠。以游标卡尺检测直肠直径,直肠标本进行苏木精-伊江染色病理检查,并行肿瘤坏死因子-αmRNA的RT-PCR检测。结果放疗后大鼠的直肠直径均有增加。蛋黄油及蛋黄油为主的复方制剂并没有减少大鼠直肠直径增加的程度。放疗后大鼠的直肠腺体均有减少,蛋黄油及复方制剂可以减少腺体的丢失,但是复方制剂和蛋黄油相比差异无统计学意义。放疗后大鼠直肠TNF-α的表达均有增加。药物处理组可以下调局部TNF-α的表达,其中复方制剂组可以更显著的减少TNF-α的表达,有统计学意义。结论蛋黄油及蛋黄油为主的复方制剂对大鼠放射性直肠炎表现出一定的疗效,其中复方制剂相比蛋黄油显示出更加优秀的疗效。
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| 关 键 词： | 放射性直肠炎 蛋黄油 肿瘤坏死因子-α 灌肠治疗 |
Compound pharmaceutics based maily on yolk oil treat on radiation proctitis of rats |
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| Affiliation: | AO Rui1,2,SUN Lan1,TU Ling-li1,et al.1.West China Hospital,West China School of Clinical Medicine,Chengdu,Sichuan University,Chengdu,Sichuan 610041;2.People′s Hospital of Sichuan,Chengdu,Sichuan 610072,China |
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| Abstract: | Objective To study the effects of compound pharmaceutics based mainly on yolk oil treated on radiation proctitis of rats.Methods 24 rats were randomly divided into 4 groups.which were defined as follows: group 1 was unirradiated and given normal saline enemas;group 2 was irradiated and given normal saline enemas;group 3 was irradiated and given yolk oil enemas;group 4 was irradiated and given compound pharmaceutics enemas.The pelvic of rats received irradiation with a dose of 16.5gy except group 1.Enemas we... |
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| Keywords: | radiation proctitis yolk oil tumor necrosis factor-α enema |
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