| 木通提取物对实验性大鼠静脉血栓形成的影响 |
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| 引用本文： | 耿涛,孟兆珂,耿令奎,刘德连,闫振国. 木通提取物对实验性大鼠静脉血栓形成的影响[J]. 中国现代应用药学, 2009, 26(6): 462-464 |
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| 作者姓名： | 耿涛 孟兆珂 耿令奎 刘德连 闫振国 |
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| 作者单位： | 1.泰山医学院附属医院，山东 泰安271000；2.泰安市肿瘤防治院, 山东 泰安 271000；3.泰山医学院, 山东 泰安 271000；4. 肥城矿业中心医院，山东 泰安 271000 |
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| 摘 要： | 目的探讨活血化瘀中药木通的提取物对大鼠实验性静脉血栓形成的影响,为木通提取物治疗静脉血栓提供实验依据。方法利用大鼠静脉血栓形成模型测定给予木通提取物100,200mg·kg^-1后血栓湿重和干重,另有模型组（给予0.9%氯化钠溶液）和阳性对照组（华法林）进行对比,分别计算其各血栓形成抑制率。结果木通提取物100mg·kg^-1组对大鼠静脉血栓形成有一定影响,木通提取物200mg·kg^-1组可以明显抑制大鼠静脉血栓形成,减轻血栓湿重和干重,对血栓湿重抑制率分别为19.9%和48.6%,对血栓干重抑制率分别为15.5%和42.8%。结论木通提取物可抑制大鼠实验性静脉血栓形成。
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| 关 键 词： | 木通提取物 大鼠 静脉血栓 |
| 收稿时间： | 1900-01-01 |
The Influence of Akebiae Extract on the Formation of Venous Thrombosis in Rats |
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| GENG Tao,MENG Zhaoke,GENG Lingkui,LIU Delian,YAN Zhenguo. The Influence of Akebiae Extract on the Formation of Venous Thrombosis in Rats[J]. The Chinese Journal of Modern Applied Pharmacy, 2009, 26(6): 462-464 |
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| Authors: | GENG Tao MENG Zhaoke GENG Lingkui LIU Delian YAN Zhenguo |
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| Affiliation: | GENG Tao, MENG Zhaoke, GENG Lingkui, LIU Delian, YAN Zhenguo(1.Affiliated Hospital of Taishan Medical College, Taian 271000, China; 2.Tumour Hospital of Taian, Taian 271000, China： 3. Taishan Medical College, Taian 271000, China; 4. The Central Hospital of Feicheng Mining Industry Bloc, Taian 271000, China) |
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| Abstract: | OBJECTIVE To isolate and determine the chemical constituents from Shengzhou Ranunculus muricatu L. . METHODS Eight compounds were isolated and purified by extraction and different kinds of column chromatography. The structures were determined on the basis |
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| Keywords: | akebiae extract rats venous thrombosis |
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