| 大鼠孤束核内注入去甲肾上腺素及其受体阻断剂对迷走-加压反应的影响 |
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| 引用本文： | 王志红,吕运明,李维新.大鼠孤束核内注入去甲肾上腺素及其受体阻断剂对迷走-加压反应的影响[J].青岛大学医学院学报,1990(2). |
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| 作者姓名： | 王志红 吕运明 李维新 |
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| 作者单位： | 青岛医学院生理学教研室，青岛医学院生理学教研室，青岛医学院生理学教研室 曲阜师范大学生物系 |
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| 摘 要： | 采用药物微量注射的方法,研究了32只大鼠孤束核(NTS)内注入去甲肾上腺素(NA)及受体阻断剂酚妥拉明和心得安对迷走-加压反应的影响.结果表明,NTS内注入NA可显著减弱迷走-加压反应;酚妥拉明可以逆转由NA引起的血压反应;心得安无此作用.结果提示,NTS内的去甲肾上腺素能神经元参与迷走加压反应过程,它对迷走加压反应的影响是通过α受体实现的.
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| 关 键 词： | 迷走加压反应 孤束核 心得安 去甲肾上腺素 酚妥拉明 |
EFFECTS OF THE NUCLEUS TRACTUS SOLITAIRIUS INJECTION OF NORADRENALINE AND ADRENERRIC BLOCKING AGENT ON VAGUS-PRESSOR RESPONSE |
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| Wang Zhihong,et al.EFFECTS OF THE NUCLEUS TRACTUS SOLITAIRIUS INJECTION OF NORADRENALINE AND ADRENERRIC BLOCKING AGENT ON VAGUS-PRESSOR RESPONSE[J].Acta Academiae Medicinae Qingdao Universitatis,1990(2). |
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| Authors: | Wang Zhihong |
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| Institution: | Wang Zhihong,et al Department of Physiology |
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| Abstract: | Thirty-two urethane anaesthetized and artificially ventilated rats were used in he experiment. A microinjection of drug into the nucleus tractus solitarius was tperformed to investigate the effect of noradrenaline and adrenergic blocking agent on vagus-pressor response (VPR). The results were as follows: 1) noradrenaline decreased the VPR value; 2)phentolamine prevented the effect of noradrenaline; 3 ) propranolol had no effect on VPR value. The results suggest that noradrenaline in the nucleus tractus solitarias appears to be a necessary transmiiter in VPr, producing its effect through the adrenoceptor. |
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| Keywords: | Vagus-pressor responses Nucleus tractus solitarius Noradrenaline Phentolamine Propranolol |
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