Effect of Escherichia coli endotoxin on cochlear potentials following its application to the chinchilla middle ear |
| |
| Authors: | T. Morizono K. Ikeda |
| |
| Affiliation: | (1) Department of Otolaryngology, University of Minnesota Medical School, Minneapolis, Minnesota, USA;(2) Department of Otolaryngology, Medical Research East, University of Minnesota Medical School, 2630 University Avenue S.E., 55414 Minneapolis, MN, USA |
| |
| Abstract: | Summary The compound action potential (CAP) of the eighth nerve and the endocochlear potential (EP) were examined in the chinchilla as an animal model when Escherichia coli endotoxin (100 g) was applied to the middle ear cavity. A significant elevation of the CAP threshold at 2, 3, and 4 kHz was observed 48h after the instillation of endotoxin, but this hearing loss was thought to be caused by a conductive component. No significant change in the CAP threshold was recognized 30 days after instillation. The EP in either period showed no significant difference. These findings indicate that the application of endotoxin at the concentration used in the present study does not cause a cochlear disturbance.Presented at the XXV Workshop on Inner Ear Biology, London, 4–7 September 1988 |
| |
| Keywords: | Endotoxin Otitis media Compound action potential Endocochlear potential Escherichia coli |
| 本文献已被 SpringerLink 等数据库收录！ |
|
