幼儿手背丘疹皮炎与病毒感染的实验研究

VIRUS INFECTION AND INFANTILE PAPULAR DERMATITIS OF DORSUM OF THE HAND

Four strains of enterovirus and 1 strain of adenovirus have been isolated from stool and pharyn-geal swab by inoeubation with primary human embryonic kidney cell culture in 25 cases of infantile , papular dermatitis of the dorsum of the hand. Two strains of Coxsackie A-9 virus and 1 strain of Echovirus-25 were identified. With the isolated virus as antigen, a matched pair study of the ser antibody test was carried out in 43 children with papular dermatitis and in 40 normal individuals as controls. In 26 cases of Coxsackie A-9 viruspositive papular dermatitis, a 4-fold rise (>1:16) of the relative serum antibody has been observed in 80%, while none of this high level was observed in patients with Echovirus-25 and adenovirus dermatitis (<1:16).We can reasonably conclude that epidemic Coxsackie A-9 virus infection was obviously related to infantile papular dermatitis and probably the main cause of the disease.