| 人脑胶质瘤WAF1／CIP1表达的研究 |
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| 引用本文： | 孙庆林,徐寿水.人脑胶质瘤WAF1／CIP1表达的研究[J].中风与神经疾病杂志,1998,15(3):151-153. |
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| 作者姓名： | 孙庆林 徐寿水 |
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| 作者单位： | 白求恩医科大学一院神经外科，解放军第４６１医院 |
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| 摘 要： | 目的检测抑癌基因ＷＡＦ１／ＣＩＰ１在人脑胶质瘤中的表达。方法取４６例胶质瘤组织及１２例脑外伤组织，提取其ｍＲＮＡ，用ＷＡＦ１／ＣＩＰ１作为模板进行逆转录ＰＣＲ（ＲＴ－ＰＣＲ）。结果４６例胶质瘤中有１４例有ＷＡＦ１／ＣＩＰ１蛋白表达（１４／４６），表达率为３０．４％，１２例脑外伤标本全部表达（１２／１２），表达率为１００％，两组比较有显著差异（Ｐ＜０．０１）。结论ＷＡＦ１／ＣＩＰ１的缺失是脑胶质瘤发生及进展的原因之一。
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| 关 键 词： | 脑胶质瘤 抑癌基因 WAF_1／CIP_1 逆转录PCR表达 |
Studies on the expression of WAF 1/CIP 1 in human glioma |
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| Sun Qinglin,Zhao Gang,Xu Shoushui.Studies on the expression of WAF 1/CIP 1 in human glioma[J].Journal of Apoplexy and Nervous Diseases,1998,15(3):151-153. |
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| Authors: | Sun Qinglin Zhao Gang Xu Shoushui |
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| Institution: | Sun Qinglin,Zhao Gang,Xu Shoushui.Department of Neurosurgery,The First Teaching Hospital of Norman Bethune University of Medical Sciences,Changchun 130021 |
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| Abstract: | Objective To study expression of cancersuppressing genes WAF 1/CIP 1 in human glioma.Method To take up the mRNA from 46 cases with brain glioma and 12 cases with brain contusion,the WAF 1/CIP 1 RNA are carry out re frans formation PCR.CRI PCR.Results 14 out of 46 cases with brain glioma show WAF 1/CIP 1(30.4%),while all in 12 cases with contusion show WAF 1/CIP 1(100%),there is a significant differece between the two groups (P<0.01).Conclusion Defect WAF 1/CIP 1 is an important cause in developing human glioma. |
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| Keywords: | Human glioma Cancer suppression WAF 1/CIP 1 re frans formation PCR expression |
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