肺癌组织中神经元特异性烯醇化酶和总RNA的表达与改变

目的：探讨神经元特异性烯醇化醇（NSE）在肺癌中表达及其诊断价值。方法：收集人肺癌，癌周及远癌组织各30份，制备和定量部RNA水平，并在肺癌组织匀浆后，分析组织中NSE的浓度变化。结果：肺癌组织NSE表达显著高于癌周及远癌组织（P＜0．01），并与总RNA浓度成正相关（r=0.04,P＜0．01），各种肺癌组织中NSE及RNA浓度无显著性差异。结论：显示肺癌组织核酸代谢旺盛，分析过度表达的NSE有助于肺癌的早期诊断。

EXPRESSION AND ALTERATION OF NEURON-SPECIFIC ENOLASE (NSE) AND TOTAL RNA IN LUNG CANCER TISSUES

Objective: To explore the expression and diagnostic value of neuron-specific enolase (NSE) in patients with lung cancer. Methods: Human lung cancerous, paracancerous and distant tissues were collected, homogenates were prepared, total RNAs were purified. The concerntrations of NSE and total RNA in tissues of 30 patients with lung cancer were investigated in this study. Results: The levels of NSE and total RNA in lung cancerous tissues were significantly higher (P<0.001) than those in paracancerous and in distant tissues. The levels of NSE expression was positively correlated with lung total RNA concerntration (P<0.01). Conclusions: The data suggest that nucleic acid metabolism is active in lung cancer tissues. Analysis of excessive expression of NSE is useful for diagnosing and distinguishing lung cancer.