| T细胞选择性核苷类似物奈拉滨 |
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| 引用本文： | 朱翊,傅得兴. T细胞选择性核苷类似物奈拉滨[J]. 中国新药杂志, 2007, 16(3): 252-255 |
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| 作者姓名： | 朱翊 傅得兴 |
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| 作者单位： | 卫生部北京医院药学部,北京,100730 |
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| 摘 要： | 奈拉滨为T细胞选择性核苷类似物，为9-β—D-阿糖呋喃糖乌嘌呤（ara—G）的水溶性前体药物，ara—G在白血病的原始细胞中转化为ara—G的三磷酸盐（ara—GTP），从而抑制DNA合成，导致细胞死亡。主要用于治疗病情复发或对药物无应答的T细胞急性淋巴细胞性白血病（T—ALL）和T细胞淋巴瘤（T—LBL）患者。现对其作用机制、药效学、药动学和临床评价做一介绍。
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| 关 键 词： | 奈拉滨 T细胞急性淋巴细胞性白血病 T细胞淋巴瘤 |
| 文章编号： | 1003-3734（2007）03-0252-04 |
| 收稿时间： | 2006-09-12 |
| 修稿时间： | 2006-09-12 |
Nelarabine, a T-cell selective nucleoside analogue |
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| ZHU Yi,FU De-xing. Nelarabine, a T-cell selective nucleoside analogue[J]. Chinese Journal of New Drugs, 2007, 16(3): 252-255 |
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| Authors: | ZHU Yi FU De-xing |
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| Affiliation: | Department of Pharmacy, Beijing Hospital, Beijing 100730, China |
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| Abstract: | Nelarabine(Arranon),a T-cell selective nucleoside analogue,is the water-soluble prodrug of 9-beta-D-arabinofuranosyl guanine(ara-G).Ara-G is converted into ara-G triphosphate(ara-GTP) inside leukemic blasts by phosphorylation,leading arrest of DNA synthesis and cell apoptosis.Nelarabine is used for patients with T-cell acute lymphoblastic leukaemia and T-cell lymphoblastic lymphoma who have not responded to other therapies or have relapsed following treatment.This review presents the bioactive mechanism,pharmacodynamics,pharmacokinetic and clinical therapeutics of nalarabine. |
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| Keywords: | nelarabine T-cell acute lymphoblastic leukaemia(T-ALL) T-cell lymphoblastic lymphoma(T-LBL) |
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