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Simultaneous occurrence of 5q? and 21q? in refractory anemia with thrombocytosis |
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| Authors: | Herman Van Den Berghe Paul Petit Angeline Broeckaert-Van Orshoven Andries Louwagie Herman De Baere Robrecht Verwilghen |
| Institution: | 1. Division of Human Genetics, Department of Human Biology, University of Leuven, Belgium;2. Division of Hematology, Department of Medical Research, University of Leuven, Belgium;3. Centre de Diagnostic Hormonal, Brussels, Belgium. |
| Abstract: | A 40-yr-old female with refractory anemia and thrombocytosis was shown to possess 5q? and 21q? chromosomal anomalies in the hematopoietic cells. The former anomaly was demonstrated to be a del(5)(q14q32) and the latter to be due to a t(11;21)(q25;q21). A similar translocation was shown to exist in the cells of another patient with essential thrombocytosis. Thus, we tentatively identify the 21q? as being due to a t(11;21). |
| Keywords: | Address reprint requests to: Dr Herman Van Den Berghe Academisch Ziekenhuis Sint-Rafaël 300 Leuven Kapucijnenvoer 33 Leuven Belgium |
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