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Chromosomes in neoplasia: An appeal for unpublished data
Authors:Felix Mitelman  Göran Levan
Affiliation:1. Department of Clinical Genetics, University Hospital, Lund, Sweden.;2. Institute of Genetics, University of Gothenburg, Sweden.
Abstract:In relation to a recent survey of chromosome aberrations in 856 human neoplasms the following points are presented: 1) the chromosome aberrations of significance to the biology of neoplasms are nonrandom; 2) aberrations of a particular chromosome tend to be of similar kind; 3) aberrations cluster to a limited number of specific chromosomes; 4) geographic differences have been observed in chromosome aberrations; 5) the karyotypic pattern of a neoplasm may be influenced by previous exposure to potential carcinogenic agents; 6) the role of chromosome aberrations in neoplasia—a hypothesis; 7) a plea is made for unpublished data to be included in our next survey of chromosome aberrations.
Keywords:Address reprint requests to: Dr. F. Mitelman   Department of Clinical Genetics   University Hospital   S-221 85 Lund   Sweden.
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