Chromosomes in neoplasia: An appeal for unpublished data |
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Authors: | Felix Mitelman Göran Levan |
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Affiliation: | 1. Department of Clinical Genetics, University Hospital, Lund, Sweden.;2. Institute of Genetics, University of Gothenburg, Sweden. |
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Abstract: | In relation to a recent survey of chromosome aberrations in 856 human neoplasms the following points are presented: 1) the chromosome aberrations of significance to the biology of neoplasms are nonrandom; 2) aberrations of a particular chromosome tend to be of similar kind; 3) aberrations cluster to a limited number of specific chromosomes; 4) geographic differences have been observed in chromosome aberrations; 5) the karyotypic pattern of a neoplasm may be influenced by previous exposure to potential carcinogenic agents; 6) the role of chromosome aberrations in neoplasia—a hypothesis; 7) a plea is made for unpublished data to be included in our next survey of chromosome aberrations. |
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Keywords: | Address reprint requests to: Dr. F. Mitelman Department of Clinical Genetics University Hospital S-221 85 Lund Sweden. |
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