CyclinD1在口腔鳞状细胞癌中表达及其意义的 Meta 分析

目的：探讨细胞周期蛋白 D1（CyclinD1）在口腔鳞状细胞癌（OSCC）组织中的表达及其与临床病理指标之间的关系。方法计算机检索 Cochrane Library、Embase、PubMed、CNKI 、VIP、万方、CBM 等数据库，按照纳入与排除标准选择研究文献，应用 Meta 分析 RevMan5．0．1软件对各研究原始数据进行统计分析，计算合并 OR 值及95％CI 。结果最终进入 Meta 分析的文献共有31篇，其中 OSCC 组1604例，对照组864例（包括正常口腔黏膜对照452例和癌前病变对照412例）；Meta 分析结果：合并 OR 值为11．92，95％CI 为6．71～21．18；CyclinD1与 OSCC 分化程度、淋巴结转移、临床分期呈正相关（P ＜0．05），而与年龄及性别无相关性（P ＞0．05）。结论 CyclinD1的过表达与 OSCC 的发生、发展密切相关，检测 CyclinD1有助于 OSCC 的早期诊断、治疗和判断预后。

Meta-analysis of expression and clinical significance of cyclinD1 in oral squamous cell carcinoma

Objective To investigate the expressions and significance of cyclinD1 in oral squamous cell carcinoma (OSCC). Methods The published studies were searched in the Cochrane Library,Embase,PubMed,CNKI,VIP,Wanfang and CBM databas-es,the quality of the included studies was assessed.Revman5.0.1 software was adopted to test for heterogeneity of the selected re-search literature and analyze the correlation of cyclinD1 and OSCC by calculating OR and 95%CI .Results A total of 31 case-con-trol studies were included in the study,the case group (OSCC group)was 1 604 cases and the control group was 864 cases (inclu-ding normal oral mucosa tissue 452 cases and precancerous lesions 412 cases).The Meta analysis of results showed that the expres-sion of CyclinD1 in oral squamous cell carcinoma was significantly higher than normal tissue[OR (95%CI )at 11.92 (6.71 -21.18)].CyclinD1 was related to differentiated degree,lymph node metastasis and clinical stage of OSCC positively(P <0.05),but was not related to age and gender (P >0.05).Conclusion According to the current relevant research,the over expression of cy-clinD1 is closely related to occurrence and development of OSCC,which might be valuable for the early diagnosis,treatment,and prognosis of OSCC.