冠心病患者血清胱抑素C水平与冠状动脉病变程度相关性分析

目的：观察肾功能正常的冠心病患者血清胱抑素C水平（Cys C）变化，探讨Cys C对冠状动脉病变严重程度的预测价值。方法检测316例肾功能正常的冠心病者及102例无冠心病者Cys C水平，从冠状动脉病变支数、冠状动脉狭窄程度、冠状动脉病变Gensini总评分三方面分析Cys C水平与冠心病之间的关系。结果冠心病组Cys C水平较对照组升高（1．24±0．32）mg／L vs ．（1．12±0．27）mg／L ， P＜0．01）]；多支病变组Cys C水平较单支病变组显著升高（1．31 ± 0．31）mg／L vs ．（1．20 ± 0．32）mg／L ，P＜0．01]；冠状动脉严重狭窄组Cys C水平较轻度狭窄组显著升高（1．29 ± 0．36）mg／L vs ．（1．16 ± 0．23）mg／L ，P＜0．01]，且冠心病患者Cys C与冠状动脉病变Gensini评分呈正相关（r＝0．195，P＜0．01）。结论冠心病患者Cys C水平增高，且与冠状动脉病变程度呈正相关。血清Cys C水平对冠状动脉病变程度具有一定的预测价值。

Relationship between serum cystatin C concentration and corornary lesions in patients with coronary heart disease

Objective To observe the changes of serum cystatin C(Cys C) in patients with coronary heart disease(CHD) and normal kidney function ,and evaluate the predictive value of Cys C concentration on coronary arterial lesions .Methods Serum levels of Cys C were detected in 316 patients with coronary heart disease and normal renal function .The relationship between serum 1evels of Cys C and coronary heart disease was evaluated from three aspects :the number of diseased vessels ,the severity of diseased ves‐sels and the CHD Gensini scores .Results The Cys C level in CHD group was significantly higher than that of non‐CHD group (1 .24 ± 0 .32)mg/L vs .(1 .12 ± 0 .27)mg/L ,P<0 .01] .Serum Cys C was significantly higher in the multi‐vessel disease group than that of the single‐vessel disease group(1 .31 ± 0 .31)mg/L vs .(1 .20 ± 0 .32)mg/L ,P<0 .01] .Serum Cys C was significantly higher in the severe coronary artery stenosis group than in the mild stenosis group (1 .29 ± 0 .36)mg/L vs .(1 .16 ± 0 .23)mg/L , P<0 .01] .Cys C was positively correlated with the Gensini scores of coronary arterial lesion (r=0 .195 ,P<0 .01) .Conclusion Cys C levels increased in patients with coronary heart disease and normal renal function .Cys C was positively correlated with the Gensini scores of coronary arterial lesion .Serum Cys C levels has certain predictive value on coronary arterial lesions in patients with CHD .