| 盐酸木防己碱的高效液相测定及在兔体内的药代动力学研究 |
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| 引用本文： | 徐克意,谭建权,叶晓炜,邱刚,戴富宝,李修禄,曾衍霖. 盐酸木防己碱的高效液相测定及在兔体内的药代动力学研究[J]. 药学学报, 1987, 22(9): 704-707 |
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| 作者姓名： | 徐克意 谭建权 叶晓炜 邱刚 戴富宝 李修禄 曾衍霖 |
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| 作者单位： | 第二军医大学训练部药理教研室，第二军医大学训练部药理教研室，药物分析教研室，第二军医大学训练部药理教研室，药物分析教研室，药物分析教研室，中国科学院上海药物研究所 上海，上海，上海 |
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| 摘 要： | 木防己[Cocculus trilobus(Thunb.)DC.]民间广泛用于解热、消炎和治疗神经痛等。我校药学系植化教研室从产于浙江临安的木防己中分离到木防己碱和异木防己碱。盐酸木防己碱(TrL)有抗炎、解热和镇痛作用,不产生身体依赖,ⅳ给药可降低猫的血压。本文报告用高效液相色谱(HPLC)测定法研究TrL在兔体内的药代动力学结果。
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| 关 键 词： | 盐酸木防己碱 高效液相色谱测定法 药代动力学 |
| 收稿时间： | 1986-10-28 |
HPLC DETERMINATION AND PHARMACOKINETIC INVESTIGATION OF TRILOBINE HYDROCHLORIDE IN RABBITS |
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| XU Ke-Yi,TAN Jian-Quan,YE Xiao-Wei,QIU Gang,DAI Fu-Bao,LI Xiu-Lu and ZENG Yan-Lin. HPLC DETERMINATION AND PHARMACOKINETIC INVESTIGATION OF TRILOBINE HYDROCHLORIDE IN RABBITS[J]. Acta pharmaceutica Sinica, 1987, 22(9): 704-707 |
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| Authors: | XU Ke-Yi TAN Jian-Quan YE Xiao-Wei QIU Gang DAI Fu-Bao LI Xiu-Lu ZENG Yan-Lin |
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| Abstract: | The pharmacokinetics of trilobine-HCl (TrL) in rabbits was studied using HPLC. Strychnine was used as an internal standard. The mobile phase consisted of methanol and ammonia (100/0.02 by vol). The flow rate was 2 ml/min. The retention times for TrL and strychnine were 5.1 rain and 9.3 min respectively. The detection limit of TrL was 7.2 ng. The HPLC method was a simple, accurate and sensitive assay method for TrL. Plasma C vs t data of TrL after ⅳ of 40 mg/kg in rabbits were fitted to curves employing PCNONLIN program. The results indicated that the data fitted a two-compartment open model adequately. The primary and secondary parameters obtained were presented in tab 1 and tab 2. |
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| Keywords: | Trilobine-HCl HPLC Pharmacokinetics |
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