Metabolic Management of Severe Acute Pancreatitis |
| |
Authors: | John A Windsor Hisham Hammodat |
| |
Institution: | (1) Department of Surgery, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand, NZ |
| |
Abstract: | The metabolic management of severe acute pancreatitis involves early identification of patients with severe pancreatitis,
aggressive fluid resuscitation, organ support, and careful monitoring in an intensive care environment. Recent evidence has
helped to define the roles of enteral feeding, prophylactic antibiotics, endoscopic retrograde cholangiopancreatography, computed
tomography, and fine-needle aspiration for bacteriology. The most difficult decision in the management of these patients is
whether surgery is required and which of the complementary approaches to necrosectomy and drainage is appropriate. Key metabolic
events in the acinar cell, pancreas, and intestines are now being unraveled, as is the basis for the systemic manifestations
and organ dysfunction associated with pancreatitis. This gives hope for the development of more specific metabolic interventions,
which will likely target the maintenance of intestinal integrity and function, preservation of pancreatic microcirculation,
and balanced modulation of the inflammatory response. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|