ＨＩＦ-１α和ＧＬＵＴ-１在卵巢癌中的表达及临床意义

目的：探讨缺氧诱导因子-１α（ｈｙｐｏｘｉａ-ｉｎｄｕｃｉｂｌｅ ｆａｃｔｏｒ-１ａｌｐｈａ，ＨＩＦ-１α）和葡萄糖转运蛋白１（ｇｌｕｃｏｓｅ ｔｒａｎｓｐｏｒｔｅｒ-１，ＧＬＵＴ-１）在卵巢癌中的表达及其与临床病理特征间的相互关系和临床意义。方法：用免疫组化法检测卵巢上皮性癌３０例、卵巢上皮性交界性肿瘤１０例、卵巢上皮性良性肿瘤１０例中ＨＩＦ-１α和ＧＬＵＴ-１的表达。结果：ＨＩＦ-ｌα和ＧＬＵＴ-１在卵巢上皮性良性肿瘤中均呈阴性表达，在交界性及癌组织中均有表达，三者比较有显著性差异（均为Ｐ＜０.０５）；ＨＩＦ-１α和ＧＬＵＴ-１的表达在卵巢癌各临床分期、患者年龄间比较，差异均无显著性（Ｐ＞０.０５），而在病理分级间有显著性差异（Ｐ＜０.０５），其表达强度随病理分级的增高而加强；ＨＩＦ-１α蛋白的表达在不同组织类型的卵巢癌中有显著性差异（Ｐ＜０.０５），而ＧＬＵＴ-１蛋白的表达差异无显著性（Ｐ＞０.０５）。ＨＩＦ-１α蛋白与ＧＬＵＴ-１的表达呈正相关。结论：ＨＩＦ-ｌα和ＧＬＵＴ-１在卵巢肿瘤中的不同表达，提示二者在卵巢癌的进展中可能起着重要作用，且二者的过度表达可能与卵巢癌的发生和发展有关。

Expression and significance of hypoxia-inducible factor-la and glucose transporter protein-1 in epithelial ovarian tumor

Objective： Discuss the expression of hypoxia-inducible factor-1 alpha （HIF-lct） and glucose transporter-1 （GLUT-1） in ovarian cancer and analyze the interrelationship and significance between these two factors and the clinicopathological characteristics. Methods：Use immunohistocbemistry to detect the expression of HIF-1α and GLUT-1 in 30 ovarian cancer samples,10 samples of benign cystadenomas and 10 samples of borderline tumors. Results：The expression rates of HIF-1α and GLUT-1 in ovarian benign tumor were negative. There were positive in ovarian borderline tumors and cancer, which had significant difference（ P 〈 0.05 ） ; the expression rates of HIF-1α and GLUT-1 had no significant differences in different ovarian cancer＇s clinical stages and ages （P 〉 0. 05 ）. But the expression had significant differences in pathological grades （ P 〈 0. 05 ）. The expression strengthened with the in- creased of pathological grades. The expression rates of HIF-1α had significant differences in ovarian cancer＇s tissue types（ P 〈 0.05 ）, but the expression rates of GLUT-1 had no significant differences（ P 〉0. 05 ）. The expression rates of HIF-1α and GLUT-1 were posi- tively associated. Conclusion：The different expression rates of HIF-1α and GLUT-1 in ovarian tumor indicates that they played impor- tant roles in ovarian cancer＇s progress. The over-expression rates of HIF-1α and indicates may be related to ovarian carcinogenesis and development.