异环磷酰胺为主化疗方案在儿童恶性疾病中的应用

１９９３年１１月至１９９５年１月１８例小儿恶性肿瘤病人接受异环磷酰胺为主的化疗共３８个疗程，异环磷酰胺剂量为每次１．３～１．７ｇ／Ｍ２×５天，同时每天给予每克异环环磷酰胺１．２ｇ美斯纳及水化、碱化，结果表明异环磷酰胺在上述用法时较为安全，可以避免主要毒性反应一出血性膀胱炎，骨随抑制时间较为短暂，未发生致死性感染，无明显肝脏毒性作用。３～１２个月短期随访结果显示异环磷酰胺对Ｂ细胞型恶性淋巴瘤、神经母细胞瘤、横纹肌肉危及肾母细胞瘤有明显效果，并在环磷酰胺抗药时仍有效。

IFOSFAMIDE-BASED CHEMOTHERAPY IN CHILDREN WITH MALIGNANI TUMOR

cmdren with malignant tumor received ifosfamide-based intensive chemother-apy for 38 protocals from 1993.1 to 1995.1.The dose of ifosfamide was 1.g/m2/d,otal 5days,companied with mesf1a 1.g/every 1g ifosfamide/d,hydration and basification. The re-sult showed that the dosage limited bladder hemorrhage could be avoided,and bone marrow sup-pression was short.Life threatening infections and obvious Iiver toxici ty were not found.3-12months following-p indicated that ifosfamide is an effective drug to B type non-Hodgkin'slymphoma,neuroblastoma,wilm's tumor and rhabdomyoblastoma even in some CTX resistancecases.