肿瘤标志物联合检测对肺癌诊断的应用价值研究

目的 探讨肿瘤标志物联合检测在肺癌诊断中的应用价值。方法将68例肺癌患者作为观察组，18例肺良性疾病患者作为对照组，空腹收集血清后，用电化学发光免疫法检测血清肿瘤标志物CEA、CYFRA21—1、CAl25、NSE。分析两组肿瘤标志物的含量及检测的敏感性、特异性。结果观察组四项肿瘤标志物含量均高于对照组，差异有统计学意义（P〈0．05）。联合检测敏感性及特异性显著高于单一肿瘤标志物检测，差异有统计学意义（P〈0．05）。腺癌组肺癌CEA血清水平高于其他组，差异有统计学意义（P〈0．05）。小细胞肺癌组NSE阳性率高于鳞癌及腺癌肺癌组，差异有统计学意义（P〈0．05）。结论肿瘤标志物联合检测诊断肺癌敏感性好，特异性高，值得临床推广应用。

Applilcation value study of tumor markers joint detection in lung cancer diagnosis

Objective To study the application value of joint detection of tumor markers to diagnosis lung cancer.Methods Sixty-eight cases of patients with lung cancer as research group,18 cases of patients with lung disease benign as the control group,collect serum while hollow,electricity chemical luminescence immunoassay detection serum tumor markers CEA,CYFRA21-1,CA125,NSE.Analysis the concentration and sensitivity and specificity of the two groups of tumor markers.Results The observation group four tumor markers content are higher than those in the control group,the difference was statistically significant(P < 0.05).United detection sensitivity and specificity significantly higher than a single tumor markers detection,the difference was statistically significant(P < 0.05).Adenocarcinoma CEA serum level of lung cancer than other groups,the difference was statistically significant(P < 0.05).Small cell lung cancer group NSE were higher than squamous cell carcinoma and adenocarcinoma lung cancer group,the difference was statistically significant(P < 0.05).Conclusion Tumor markers united detection sensitivity to diagnose lung cancer,highly specific,and worth to application at clinical.