Excitatory inputs to CA1 interneurons show selective synaptic dynamics |
| |
Authors: | Wierenga Corette J Wadman Wytse J |
| |
Institution: | Swammerdam Institute for Life Sciences, Section Neurobiology, University of Amsterdam, 1098 SM Amsterdam, Netherlands. |
| |
Abstract: | The dynamic properties of synapses between neurons in the hippocampal CA1 area are important for the frequency-dependent signal transfer of the network. We have examined the synaptic dynamics of excitatory inputs to CA1 interneurons and pyramidal cells using whole cell voltage-clamp recordings. The CA1 network was activated using extracellular stimulation electrodes at the Schaffer collaterals (feedforward activation) or at the Alveus (activation of the feedback loop). The dynamic properties of input from the Schaffer collaterals to CA1 interneurons (basket and bistratified cells) were different from the synaptic dynamics of input from the Alveus. Synaptic input from the Schaffer collaterals to CA1 interneurons showed facilitation for most frequencies. After 10 stimuli the synaptic response reached a plateau level that was approximately 150% of the first response in the train. In contrast, the plateau levels of Alveus inputs to interneurons were not different from the first responses for frequencies
|
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
| 点击此处可从《Journal of neurophysiology》浏览原始摘要信息 |
| 点击此处可从《Journal of neurophysiology》下载免费的PDF全文 |