对间日疟原虫配子体活力消长的进一步观察

以常用的体外吸血法,对2例人工接种大量子孢子、发病后未用抗疟药治疗的间日疟现症病例,每天在发作间歇期,取静脉血感染驯化的中华按蚊,直至原虫密度下降,病程自然结束为止。结果表明,间日疟病例在临床发作的第1天对按蚊即有感染性,感染高峰见于第8病日之前,自第9病日显著下降。高感染度的持续时间极短,1例为3天,另1例为4天,分别见于发病的第4~6天和第3~6天,相当于1.5~3个无性体裂体增殖周期,以后一直维持在很低水平,且无上升趋势。由此可见,早期发现和及时治疗,在疟疾防治工作中具有重要意义;在科研工作中,凡需大量子孢子进行实验研究时,选择发作不超过3次、原虫血症较高的早期现症病例作为传染源最为适宜。

Further Studies on the Rise and Decline of Plasmodivm Vivax Gametocyte Viability

This paper deals with the infectivity of gametocytes for Anopheles sinensis in two cases artificially infected with vivax malaria. The results obtained in this study indicated that the mosquitoes have become infected on the first day of illness and that the percentage of infected mosquitoes came to a peak on 2 to 8 days after the first appearance of clinical signs. Following this the infectivity declined obviously. The average oocyst count tends to reach its peak in each participant on 3 to 6 days, after which on day 7 it falls abruptly and remains fairly low without fluctuation until the acute symptoms subsides by immun response of the host.
We suggested that the data recorded here provide the most favorable time to obtain Plasmodium vivax infection in mosquitoes and this information has been of value in experimental investigations where a large number of sporozoites were required.