278株痰肺炎克雷伯菌耐药性分析

目的分析痰肺炎克雷伯菌的耐药性。方法使用VITEK-32全自动微生物分析系统进行细菌的鉴定、药物敏感性试验及ESBLs检测。结果278株痰肺炎克雷伯菌对AMP的耐药率98．56％。对IMI耐药率为0，对TZP耐药率为9．7％，AMK为12．23％，对AMPS、CIP、CTR、FD、FEP、GM、TOB耐药率均在30％以下，对CZ、SXT、ROX、ROXA、LEV耐药率均在30％～40％之间。产ESBLs株占19．06％，产ESBLs株对多种抗生素的耐药率高于不产ESBLs株，差异有统计学意义。结论痰肺炎克雷伯菌多种抗生素耐药，对IMI均敏感，对AMP耐药率最高，产ESBLs株耐药率高于不产ESBLs株。

Antimicrobial Resistance analysis of 278 strains Klebsiella pneumoniae from sputum

Objective To analyze the antimicrobial resistance of 278 strains klebsiella pneumoniae from sputum sample. Methods Klebsiella pneumoniae was cultured and isolated from sputum, The strain identification, antimicrobial susceptibility test and extended spectrum β-lactamases (ESBLs) identification were measured by VITEK-32 full automated microbiology analyzer. Results The antimicrobial resistance percentage to ampicillin was 98.56%, imipenem was 0, Piperacillin/ tazobactam was 9.7%, amikacin was 12.23%, ampicillin/sulbactam、ciprofloxacin、ceftriaxone、nitrofurantoin、cefepime gentamicin and tobramycin was lower than 30%, to cefazolin、sulfamethoxazole/trimethoprim、cefuroxime、cefuroxime axetil and levofloxacin was between 30% and 40%. The percentage of ESBLs strains was 19.06%, The resistance percentage of ESBLs strains was higher than non-ESBLs strains. Conclusion Klebsiella pneumoniae from sputum was resistant to quite a few of antibiotics, was sensitive to imipenem. The resistance percentage to ampicillin was the highest. The resistance percentage of ESBLs strains was higher than non-ESBLs strains.