分枝杆菌多糖对小鼠造血功能的影响

观察了分枝杆菌多糖（ＭＰＳ）对环磷酰胺抑制ＢＡＬＢ／ｃ小鼠骨髓作用的影响。结果表明：给予ＣＰＡ使小鼠骨髓ＧＭ－ＣＦＵ抑制约３０％左右。１．０ｍｇ／ｋｇ的ＭＰＳ对ＧＭ－ＣＦＵ有促进作用（第１批实验ＣＰＡ对照组３１６．５±３４．６，实验１组４５４．５±１９．１，Ｐ＜０．０５；第２批实验ＣＰＡ对照组２０８．７±４３．７，实验２组４３７．８±５４．１，Ｐ＜０．０２）；而０．１５ｍｇ／ｋｇＭＰＳ无促进作用。在０．１５和１．０ｍｇ／ｋｇ剂量下，小鼠血清ＧＭ－ＣＳＦ活性水平明显提高；０．１５和１．０ｍｇ／ｋｇＭＰＳ可分别刺激小鼠每０．１ｍＬ血清产生５００Ｕ和８５０ＵＧＭ－ＣＳＦ。分析认为ＭＰＳ与日本的Ｚ－１００活性水平相当，这些作用可能通过激活单核或Ｔ细胞而间接产生。

Effects of MPS on the Hemopoietic Function of Mice

We studied the effects of Mycobacterial polysaccharides(MPS)on the suppression function of cyclophosphamide to BALB/C mice bone marrow.The results showed that 1.0 mg/kg of MPS had enhance effects on the GM-CFU(control-1,316.5±34.6,MPS group,454.5±19.1 ,P<0.05;control-2,208.7±43.7,MPS group,437.8±54.1, P<0.02). However,in 0.15 mg/ kg and 1.0 mg/kg of MPS,the levels of GM-CSF activity in sera of mice raised obviously;0.15 mg/kg of MPS could stimulate mice to produce 500 U GM-CSF per 0.1 mL sera,1.0 mg/kg of MPS could make mice induce 850 U GM-CSF per 0.1 mL sera.Analysis indicated that the activity levels of the MPS was the same as Japanese Z-100,and the hemopoietic effects of MPS may be indirect by stimulating monocytes and T lymphacytes indirectly.