| K-ras突变多肽与全细胞抗原致敏DCs诱导CTLs对胰腺癌的杀伤活性研究 |
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| 作者单位： | Department of General Surgery,The First Affiliated Hospital of Dalian Medical University,Dalian 116011,China |
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| 收稿时间： | 2007-06-27 |
Anti-tumor effect of CTLs activated by dendritic cells pulsed with K-ras mutant peptide and whole tumor antigen on pancreatic cancer |
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| Guang Tan,Zhongyu Wang,Xin Zhang,Zhengang Cai,Junkai Zhang. Anti-tumor effect of CTLs activated by dendritic cells pulsed with K-ras mutant peptide and whole tumor antigen on pancreatic cancer[J]. The Chinese-German Journal of Clinical Oncology, 2010, 9(12): 724-729. DOI: 10.1007/s10330-010-0707-1 |
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| Authors: | Guang Tan Zhongyu Wang Xin Zhang Zhengang Cai Junkai Zhang |
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| Affiliation: | (1) Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655-0243, USA |
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| Abstract: | Objective We studied the role of specific cytotoxic T lymphocytes (CTLs) activated by dendritic cells (DCs) presenting cationic nanoparticles with the K-ras (12-Val) mutant peptide and whole tumor antigen in the killing of different pancreatic cancer cell lines in vitro and in vitro. |
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