| 丹酚酸A对照品的制备与分析 |
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| 引用本文： | 李志刚,倪广才,渠守峰,刘严,丁锐,余立.丹酚酸A对照品的制备与分析[J].药物分析杂志,2012(6):1013-1016. |
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| 作者姓名： | 李志刚 倪广才 渠守峰 刘严 丁锐 余立 |
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| 作者单位： | 北京本草天源药物研究院;北京市药品检验所 |
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| 基金项目： | “重大新药创制”科技重大专项(2011ZX09102-002-06) |
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| 摘 要： | 目的:制备丹酚酸A对照品并进行纯度分析。方法:柱层析分离纯化丹酚酸A,采用UV、IR、NMR、MS确证结构,TLC及HPLC方法检查纯度。结果:丹酚酸A纯度为99.5%。结论:丹酚酸A的纯度达到新药研究所需对照品的要求。
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| 关 键 词： | 丹酚酸A 对照品 紫外吸收光谱 红外吸收光谱 核磁共振氢谱 核磁共振碳谱 质谱 高效液相色谱 薄层色谱 |
Preparation and analysis of salvianolic acid A reference substance |
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| LI Zhi-gang,NI Guang-cai,QU Shou-feng,LIU Yan,DING Rui,YU Li.Preparation and analysis of salvianolic acid A reference substance[J].Chinese Journal of Pharmaceutical Analysis,2012(6):1013-1016. |
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| Authors: | LI Zhi-gang NI Guang-cai QU Shou-feng LIU Yan DING Rui YU Li |
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| Institution: | 1.Beijing Bencao Tianyuan Institute of Pharmaceutical Research,Beijing 100039,China;2.Beijing Institute for Drug Control,Beijing 100035,China) |
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| Abstract: | Objective:To investigate the preparation of the reference substance of salvianolic acid A from Salvia miltiorrhiza Bge.Methods:Salvianolic acid A was isolated and purified by columns chromatography.The structure and purity of salvianolic acid A was determined by UV,IR,NMR,MS,TLC and HPLC.Results:The purity of salvianolic acid A was 99.5%.Conclusion:The purity of salvianolic acid A is agreed with the standard of the reference substance. |
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| Keywords: | salvianolic acid A reference substance UV IR H1-NMR C13-NMR MS HPLC TLC |
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