ER、PR的表达与乳腺癌患者化疗相关认知障碍的相关性研究

目的：探讨雌激素受体( ER)和孕激素受体( PR)与乳腺癌患者化疗相关认知障碍( CICI)的相关性。方法60例术后辅助化疗后乳腺癌患者作为乳腺癌组,其中 ER 和PR双阴性患者30例为A组、ER和PR双阳性患者30例为B组；另以年龄及教育程度相匹配的60例健康女性志愿者为对照组。分别对其进行简易精神状态量表( MMSE)和中文听觉词语学习测验( AVLT)测查。结果乳腺癌组与对照组MMSE成绩相比差异有统计学意义( t =-12．824, P <0．05)；A组和B组在MMSE、即刻记忆和延迟记忆成绩方面差异均有统计学意义( t=-3．311、-3．616、-2．264, P<0．05)。结论化疗后乳腺癌患者存在不同程度的认知功能障碍,且ER和PR双阴性患者在总体认知功能及记忆方面损害较ER和PR双阳性患者显著( P<0．05),提示ER、PR的不同表达可能与乳腺癌CICI的异质性有关。

Correlative study of the expression of ER,PR and breast cancer patients chemotherapy-induced cognitive impairment

Objective To investigate the correlation between estrogen receptor ( ER) , progesterone receptor ( PR)and chemotherapy-induced cognitive impairment( CICI) of patients with breast cancer. Methods Take 60 breast cancer patients who had received adjuvant chemotherapy after operation as breast cancer group, in which group A included 30 patients with ER and PR double negative, group B included 30 patients with ER and PR double posi-tive. In addition, we also selected 60 cases of healthy women volunteers with age and education level matched as control group. All participants were administered with mini mental state examination ( MMSE) and auditory verbal learning test ( AVLT) tasks. Results Differences of MMSE score between breast cancer group and control group were statistically significant (t= -12. 824, P<0. 05;diifferences between group A and group B in MMSE socre, immediate memory and delay memory score were statistically significant ( t = -3. 311 , -3. 616 , -2. 264 , P <0. 05 ) . Conclusion Patients with breast cancer after chemotherapy exist in different extent of cognitive impair-ment , and the general cognitive function and memory damage of patients with ER and PR double negative are obvi-ous while comparing to patients with ER and PR double positive ( P<0. 05 ) , implying that different ER and PR expression may be related to the heterogeneity of CICI in breast cancer .