| 调节性T淋巴细胞与反复体外受精-胚胎移植的研究 |
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| 引用本文： | 许园园,刘雨生. 调节性T淋巴细胞与反复体外受精-胚胎移植的研究[J]. 临床输血与检验, 2009, 11(2): 120-122. DOI: 10.3969/j.issn.1671-2587.2009.02.07 |
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| 作者姓名： | 许园园 刘雨生 |
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| 作者单位： | 安徽医科大学附属省立医院,合肥,230001;安徽医科大学附属省立医院,合肥,230001 |
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| 摘 要： | 目的探讨外周血中调节性T淋巴细胞与反复体外受精-胚胎移植失败之间的相关性。方法用双荧光标记流式细胞分析技术，检测20例原因不明反复体外受精-胚胎移植失败患者、20例正常非孕妇女及18例第一周期体外受精-胚胎移植成功妇女外周血中CD4^＋CD25^＋调节性T淋巴细胞及CD4^＋CD25^highT细胞的水平。结果反复体外受精-胚胎移植失败患者外周血中CD4^＋CD25^＋调节性T淋巴细胞及CD4^＋CD25^highT细胞的百分率分别为（7．89±1．16）%和（1．06±0．33）％，低于正常非孕组的（11．73±1．05）％（P〈0．01）和（1．36±o．53）％（P〈0．05），也低于第一周期体外受精-胚胎移植成功组的（9．67±1．87）％（P〈0．05）和（1．39±0．37）％（P〈0．05）。结论外周血中调节性T细胞的减少可能与反复体外受精-胚胎移植失败的发生有关。
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| 关 键 词： | 体外受精-胚胎移植 CD4+CD25+调节性T细胞 CD4+CD25highT细胞 |
Research into CD4~+CD25~+ Regulatory T Cells and Unexplained Recurrent in vitro Fertilization Embryo Transplant Failure |
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| XU Yuan-yuan,LIU Yu-sheng. Research into CD4~+CD25~+ Regulatory T Cells and Unexplained Recurrent in vitro Fertilization Embryo Transplant Failure[J]. Journal of Clinical Transfusion and Laboratory Medicine, 2009, 11(2): 120-122. DOI: 10.3969/j.issn.1671-2587.2009.02.07 |
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| Authors: | XU Yuan-yuan LIU Yu-sheng |
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| Affiliation: | XU Yuan-yuan,LIU Yu-sheng.Affiliated Provincial Hospital,Anhui Medical University,Hefei 230001 |
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| Abstract: | Objective To investigate the relationship between CD4+CD25+ regulatory T cells(CD4+CD25+ Tr) and unexplained recurrent in vitro fertilization-embryo transplant(IVF-ET) failure.Methods The persentage of CD4+CD25+Tr cells was determined by double-label flow cytometric analysis.The samples were taken from 20 recurrent IVF-ET women,20 normal non-preganancy women and 18 women succeeded in the first IVF-ET cycle.Results The persentage of CD4+CD25+Tr cells and CD4+CD25highT cells were decreased significantly in re... |
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| Keywords: | IVF-ET CD4+CD25+regulatory T cells CD4+CD25highT cell |
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