| 血管紧张素转化酶抑制剂对缺氧再复氧大鼠心肌细胞超微结构的保护作用 |
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| 引用本文： | 张建青,刘伊丽,赖世忠,刘俭.血管紧张素转化酶抑制剂对缺氧再复氧大鼠心肌细胞超微结构的保护作用[J].南方医科大学学报,1995(3). |
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| 作者姓名： | 张建青 刘伊丽 赖世忠 刘俭 |
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| 作者单位： | 南方医院心内科 |
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| 摘 要： | 观察到血管紧张素转化酶仰制剂卡托普利和依那普利拉对缺氧再复氧和模拟缺血再灌注所致大鼠心肌细胞超微结构的损伤具有保护作用。两种血管紧张素转化酶抑制剂均能明显减轻心肌细胞超微结构损伤，尤其是线位体的损伤。
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| 关 键 词： | 血管紧张素转化酶抑制剂，缺氧再复氧，缺血再灌注，心肌，超微结构 |
Protective effects of angiotensin converting enzyme inhibitors on ultrastructural damage of
cardiac myocytes induced by anoxia-reoxygenation |
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| Zhang Jianqing,Liu Yili,Lai Shizhong,Liu Jian Nanfang Hospital,First Military Medical University,Guangzhou Cultured.Protective effects of angiotensin converting enzyme inhibitors on ultrastructural damage of
cardiac myocytes induced by anoxia-reoxygenation[J].Journal of Southern Medical University,1995(3). |
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| Authors: | Zhang Jianqing Liu Yili Lai Shizhong Liu Jian Nanfang Hospital First Military Medical University Guangzhou Cultured |
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| Institution: | Zhang Jianqing,Liu Yili,Lai Shizhong,Liu Jian Nanfang Hospital,First Military Medical University,Guangzhou 510515 Cultured |
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| Abstract: | rat cardiac myocytes were exposed to anoxiareoxygenation,and
ischemia-reperfusionmimicking solution with or without captopril or enalaprilat.Electron
micoroscopy of myocardial cellsshowed that both captopril and enalaprilat significantly
reduced ultrastrutural damage. The results suggestthat angiotensin converting enzyme
inhibitors are effective against the anoxia-reoxygenation damage of cul-tured rat myocardial
cells. |
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| Keywords: | angiotensin converting enzyme inhibitor anoxiareoxygenation mimicked ischemia-reper- fusion ultrastructure |
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