Genotypic linkages of VP4, VP6, VP7, NSP4, NSP5 genes of rotaviruses circulating among children with acute gastroenteritis in Thailand |
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| Authors: | Pattara Khamrin Niwat Maneekarn Rungnapa Malasao Tuan Anh Nguyen Shinichi Ishida Shoko Okitsu Hiroshi Ushijima |
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| Institution: | 1. Department of Internal Medicine, Jinshan Hospital, Fudan University, No. 1508 Longhang Road, Shanghai 201508, China;2. Rollins School of Public Health, Emory University, 1518 Clifton Road, Atlanta, GA 30322, USA;1. Departament de Química Inorgànica, Universitat de València, 46100-Burjassot, Valencia, Spain;2. Centro de Ecología Química Agrícola, Instituto Agroforestal del Mediterráneo, Universidad Politécnica de Valencia, 46022 Valencia, Spain;3. Instituto de Biología Molecular y Celular de Plantas, CSIC - UPV, Ciudad Politécnica de la Innovación, 46022 Valencia, Spain;4. Departamento de Química Inorgánica, Universidad de Santiago de Compostela, 15782 Santiago de Compostela, Spain;5. Institut de Ciència Molecular, Universitat de València, 46980-Paterna, Valencia, Spain;1. Division of Microbiology, Department of Pathology and Microbiology, Nihon University School of Medicine, Tokyo, Japan;2. Department of Developmental Medical Sciences, School of International Health, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan;3. Department of Virology II, National Institute of Infectious Disease, Tokyo, Japan;1. Laboratory of Molecular Microbiology, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia;2. Novosibirsk State University, Novosibirsk, Russia;3. Municipal Children''s Hospital No. 3, Novosibirsk, Russia |
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| Abstract: | Rotavirus is the main cause of acute viral gastroenteritis in infants and young children worldwide. Surveillance of group A rotavirus has been conducted in Chiang Mai, Thailand since 1987 up to 2004 and those studies revealed that group A rotavirus was responsible for about 20-61% of diarrheal diseases in hospitalized cases. In this study, we reported the continuing surveillance of group A rotavirus in 2005 and found that group A rotavirus was detected in 43 out of 147 (29.3%) stool samples. Five different G and P genotype combinations were detected, G1P8] (27 strains), G2P4] (12 strains), G9P8] (2 strains), G3P8] (1 strain), and G3P10] (1 strain). In addition, analysis of their genotypic linkages of G (VP7), P (VP4), I (VP6), E (NSP4), and H (NSP5) genotypes demonstrated that the rotaviruses circulating in Chiang Mai, Thailand carried 3 unique linkage patterns. The G1P8], G3P8], and G9P8] strains carried their VP6, NSP4, NSP5 genotypes of I1, E1, H1, respectively. The G2P4] strains were linked with I2, E2, H2 genotypes, while an uncommon G3P10] genotype carried unique genotypes of I8, E3 and H6. These findings provide the overall picture of genotypic linkage data of rotavirus strains circulating in Chiang Mai, Thailand. |
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