甲基苯丙胺成瘾男性患者脑白质结构网络特征研究

目的:探讨甲基苯丙胺（methamphetamine， MA）成瘾患者脑白质结构网络的拓扑特征。方法:2014年2月至2019年10月，基于弥散张量成像数据，利用概率纤维追踪技术构建MA成瘾男性患者（MA组， n=46）及男性健康对照者（对照组， n=46）的脑白质结构网络。应用基于网络的统计方...

Aberrant topology of white matter networks in male patients with methamphetamine dependence

Objective To investigate the topological alterations of white matter networks in methamphetamine(MA)-dependent patients.Methods Diffusion tensor imaging(DTI)-based probabilistic tractography was used to map the white matter networks in 46 male MA-dependent patients(MA group)and 46 male healthy controls(control group).A network-based statistic(NBS)approach was used to evaluate the differences in the white matter connections between the two groups,and then a general linear model was used to compare the topological properties between two groups,and the correlation between the network parameters with significant differences between groups and the clinical variables were analyzed.Results The study found the brain structural network for both MA group and control group presented with characteristics of a small-world network.The significantly increased structural connections in the MA group are mainly located in the reward system and visual system.The shortest path length in MA group was significantly reduced,while the clustering coefficient,global efficiency and local efficiency were significantly increased(t=-2.890,3.179,3.918,3.077,P<0.01 after the 10000 permutation test).The study also found that the betweenness centrality in MA group was significantly reduced in the orbitofrontal cortex and the parietal temporal cortex,while the left ventral anterior insula was significantly increased(P<0.05 after the 5000 permutation test).In addition,the betweenness centrality of the right thalamus,the left superior frontal gyrus,left precuneus,right precuneus,left middle temporal gyrus,and right superior marginal gyrus was negatively correlated to the lack of vitality factor score in the BPRS,and the negative correlations were found between the betweenness centrality of the right corpus callosum sulcus and the thinking disorder factor score,and the betweenness centrality of the right thalamus was also negatively correlated with total BPRS score as well as the activity factor score;the correlation coefficients r and P were r=-0.410,P=0.005;r=-0.331,P=0.026;r=-0.410,P=0.005;r=-0.337,P=0.024;r=-0.341,P=0.022;r=-0.317,P=0.034;r=-0.318,P=0.033;r=-0.342,P=0.022;r=-0.326,P=0.029,respectively.Conclusions The brain structural network of MA-dependent patients still present with the characters of small-world network,and the efficiency of information transmission and integration between brain regions is significantly speeding up,and the betweenness centrality of some brain regions can some what reflect the severity of psychotic symptoms.