酒依赖患者急性脱瘾治疗后大脑皮质厚度的磁共振成像研究

目的:探索急性脱瘾治疗后酒依赖患者脑区皮质厚度的异常特征及与酒依赖临床特征的关联。方法:以2017年4月至2018年4月的住院男性酒依赖患者（患者组， n=33）与年龄、受教育程度匹配的健康对照（对照组， n=35）为研究对象，收集大脑皮质功能磁共振的影像学数据和患者一般人口学及临床资料；使用F...

Magnetic resonance imaging study of cerebral cortex thicknesses in alcohol dependent patients after acute detoxication

Objective To explore the abnormal features of cortical thickness of brain regions in patients with alcohol dependence(PADs)after acute detoxication and the correlation with clinical features of PADs.Methods In this study,male inpatients with alcohol dependence(patient group,n=33)and healthy controls(control group,n=35)matched with age and education were enrolled during the period of Apr 2017 to Apr 2018.Brain functional magnetic resonance imaging(MRI)data,general demographic and clinical information were collected.FreeSurfer software was used to process the MRI data and compute the bilateral cortical thickness across 74 brain regions.Analysis of covariance(ANCOVA)was performed to analyse the differences of cortical thickness in different brain regions between the two groups,and the correlation between the cortex thickness and their clinical features in PADs was explored by using correlation analysis.Results Compared with HCs,PADs showed significantly decreased cortical thickness of brain regions in the left middle and pole occipital,right superior occipital gyri,bilateral superior and inferior parietal gyri,and right intraparietal sulcus(all P<0.00034,after Bonferroni correction).Positive correlation was found between the thickness of left superior parietal gyrus(SPG)and initial drinking age(r=0.428,P=0.024)in PADs.Conclusion The cortex thickness reduction of bilateral posterior parietal cortex might be a more characteristic injury in PADs.Furthermore,the initial drinking age may have a more obvious effect on the cortex of the left SPG.