| 炎症相关因子在脑缺血再灌注损伤中的研究进展 |
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| 引用本文： | 刘馨,张建忠.炎症相关因子在脑缺血再灌注损伤中的研究进展[J].川北医学院学报,2014,29(3):237-242. |
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| 作者姓名： | 刘馨 张建忠 |
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| 作者单位： | 刘馨 (川北医学院病理教研室,四川南充,637000)； 张建忠(宁夏医科大学基础医学院病理学系,宁夏回族自治区颅脑疾病重点实验室—省部共建国家重点实验室培育基地,宁夏银川 750004)； |
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| 基金项目： | 国家自然科学基金项目(项目编号：81060105) |
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| 摘 要： | 急性脑梗死患者在发病前常合并糖尿病或在发病急性期常可见血糖升高,许多临床及动物实验亦表明高血糖可加重脑缺血再灌注损伤。目前,较多的研究兴趣集中在缺血再灌注后的炎性过程,缺血细胞以及缺血激活的内皮细胞、白细胞,产生促炎性细胞因子,表达黏附分子,导致白细胞积聚和外流。该文主要综述炎症因子在高血糖脑缺血再灌注损伤中的研究进展。
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| 关 键 词： | 脑缺血再灌注损伤 炎症 细胞因子 高血糖 |
The research development of relative factors of inflammation in the impairment of cerebral ischemia reperfusion |
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| LIU Xin,ZHANG Jian-zhong.The research development of relative factors of inflammation in the impairment of cerebral ischemia reperfusion[J].Journal of North Sichuan Medical College,2014,29(3):237-242. |
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| Authors: | LIU Xin ZHANG Jian-zhong |
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| Institution: | 1. Department of Pathology, North Sichuan Medical College, Nanchong 637000, Sichuan, China ; 2. Department of Pathology of School of Basic Medicine, Ningxia Medical College, Ningxia Key Laboratory of Cerebrocranial Disease-Incubation Base of National Key Laboratory, Yinchuan 750004, Ningxia , China) |
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| Abstract: | Prior to the illness onset,the patients with acute cerebral infarction will have diabetes or a rise in blood sugar during the flare-ups. Many clinical and animal experiments show that the hyperglycemia would aggravate the impairment of cerebral ischemia reperfusion. Nowadays,more researches focus on the inflammatory process after the ischemia reperfusion. Ischemic cells,endothelial cells and leukocytes inspired by ischemia will produce pro-inflammatory cells and adhension molecule. It also causes the gathering and outflow of leukocytes. This paper mainly literally reviews the development of inflammation factors in the impairment of cerebral ischemia reperfusion. |
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| Keywords: | Impairment of cerebral ischemia reperfusion Inflammation Cells Hyperglycemia |
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