阻塞性睡眠呼吸暂停低通气综合征患者记忆功能的研究

目的探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者记忆功能与OSAHS严重程度的关系，为临床干预提供依据。方法选择我院2010年10月～2013年10月呼吸睡眠门诊经整夜多导睡眠监测（PSG）确诊为OSAHS且其他方面正常的患者150例，应用英国Rivermead康复中心设计的行为记忆测验第二版（RBMFII）对患者进行记忆功能评估。根据呼吸暂停低通气指数（AHI）将患者分为3组：轻度OSAHS（AHI10～20次／h）；中度OSAHS（AHI20-40次／h）；重度OSAHS（AHI≥40次／h），比较各组患者的记忆功能评分结果。结果不同程度的OSAHS患者记忆障碍的患病率及程度与夜间发生AHI密切相关。重度OSAHS患者的RBMFII初评分与轻、中度OSAHS患者比较，在回忆姓名、回忆被藏物品、脸部再认、路线延迟回忆、定向测试和日期等6项初评分及总标准分方面，差异有统计学意义（P〈0．05）。中度OSAHS患者与轻度OSAHS患者比较，在回忆姓名、回忆被藏物品、回忆预约、脸部再认和日期等5项初评分及总标准分方面，差异有统计学意义（P〈0．05）。轻度OSAHS患者与对照组比较，除回忆姓名评分差异有统计学意义（P〈0．05），在被藏物品、脸部再认、定向等3项初评分及总标准分方面，差异均无统计学意义（P〉0．05）。结论OSAHS患者记忆功能损害程度与病情分级相关，记忆功能减退在中、重OSAHS患者（AHI≥20次／h）中发生率较高。

The Study on Detecting the Development of Memory Dysfunction in Patients with Obstructive Sleep Apnea Hypopnea Syndrome

Objective To investigate the impact on memory dysfunction in patients with obstructive sleep apnea hypopnea syndrome （OSAHS） and examine the relation between severity of OSAHS and memory dysfunction. Methods A total of 150 patients with obstructive sleep apnea hypopnea syndrome were included and memory function was measured by the Rivermead Behavioral Memory Test （Second Edition of RBMF II 2003）. According to apnea-hypopnea index（AHI）, subjects were classified into three groups： mild OSAHS （AHI 10-20 times/h）; moderate OSAHS （AHI 20-40 times/h） and severe OSAHS （AHI ≥40 times/h）, and parameters were compared among the three groups. Results Varying degrees of memory disorders in patients with OSAHS prevalence and degree of nocturnal apnea-hypopnea index （AHI） are closely related. The ability of recall name, remember storing article, facial recognition, delayed route memory , orientation score and RBMF II total score in severe OSAHS group were significantly lower than the moderate OSAHS group and were statistically significant. Meanwhile, there were also significantly lower in moderate OSAHS group compared to the mild OSAHS group （P 〈0. 05）. Mild OSAHS patients compared with the control group, in addition to the name recall scores were significantly （P〈 0. 05）, the difference was not statistically significant in the remember storing article, facial recognition,delayed route memory, orientation score and RBMF II total score （P〉0. 05）. Conclusion The degree of memory impairment is associated with disease classification in patients with OSAHS. There is a high incidence of memory dysfunction in moderate and severe OSAHS patients （AHI ≥ 20 times / h）.