急性移植物抗宿主病的诊疗进展

移植物抗宿主病（GVHD）是异基因造血干细胞移植最常见的并发症,分为急性（aGVHD）和慢性（cGVHD）2种类型,其中aGVHD是供者T细胞识别不匹配的宿主多态性组织相容性抗原（MHC）而发生的免疫应答,具有独特发病机制,病理改变及临床表现复杂,可累及多个器官.文章就目前国内外对aGVHD的诊疗进展进行综述.

Progress in diagnosis and treatment of acute graft versus host disease

Graft versus host disease is the most common complication of allogeneic hematopoietic stem cell transplantation.It includes two different types,i.e.acute and chronic types.Acute graft versus host disease （aGVHD） is the immune response of T cells from the donor to unmatched major histocompatibility complex （MHC） from the host.It has unique pathogenesis and pathological changes and complex clinical manifestations with multiple organs involved.This paper reviewed the progress from home and abroad in diagnosis and treatment of acute graft versus host disease.