| 厚朴叶抗抑郁作用的初步研究 |
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| 引用本文： | 龙飞,韩小勤,龙绍疆,卫莹芳,吴兵.厚朴叶抗抑郁作用的初步研究[J].成都中医药大学学报,2014,37(1):39-41. |
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| 作者姓名： | 龙飞 韩小勤 龙绍疆 卫莹芳 吴兵 |
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| 作者单位： | 龙飞 (成都中医药大学,四川成都,611137)； 韩小勤 (四川滇虹医药开发有限公司,四川成都,611731)； 龙绍疆 (四川滇虹医药开发有限公司,四川成都,611731)； 卫莹芳 (成都中医药大学,四川成都,611137)； 吴兵 (成都中医药大学,四川成都,611137)； |
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| 基金项目： | 教育部博士点基金项目(项目编号：200806330006)科技部“十一五”国家科技支撑项目(项目编号：2009BAI84B03) |
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| 摘 要： | 目的：对厚朴叶醇提物抗抑郁作用进行药效研究，为开发新的抗抑郁中药提供科学依据。方法：选用小鼠强迫游泳实验和小鼠悬尾绝望实验动物模型对厚朴叶醇提物抗抑郁作用进行研究。结果：厚朴叶醇提物高、中、低3个剂量组均在一定程度减少小鼠游泳不动时间，但与空白组比较无显著性差异；厚朴叶醇提物高、中、低3个剂量组均在一定程度上减少小鼠悬尾不动时间，中剂量组显著缩短悬尾不动时间，与空白组比较有显著性差异。结论：厚朴叶醇提物具有抗一定的抑郁作用，有必要进一步探讨其作用机制。
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| 关 键 词： | 厚朴叶 抗抑郁 阿米替林 强迫游泳实验 悬尾实验 |
Preliminary Study on Antidepressant Effect of Leaves of Magnolia Officinalis Rehd. et Wils. |
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| Institution: | LONG Fei HAN Xiao-qin LONG Shao-jiang, et al ( 1. Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China; 2. Siehuan Dianhong Medical Development Co. , Ltd. , Chengdu, 611731, China) |
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| Abstract: | Objective： To study the antidepressant efficacy of alcohol extracts of leaves of Magnolia officinalis Rehd. et Wils. and provide experimental evidence for the development of Chinese antidepressant medicine. Methods： Forced swimming test and tail suspension despair experimental animal models in mouse were used to evaluate antidepressant activities. Results： In the mouse forced swimming test, three-dose leval of alcohol extracts were able to decrease the duration of immobility, but no significant differ- ence can be found so far compared with the control group; The mouse tail suspension test gives the same result, especially the medium dose, which shows a significant difference compared with the control group. Conclusion： Acording to experimental datas, the alcohol extracts may have antidepressant effect, but more researchs are needed to verify it. |
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| Keywords: | Leaves of Magnolia offtcinalis Rehd et Wils antidepressant amitriptyline forced swimming test tail sus-t~ension test |
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