| 伴有二次打击的弥漫大B细胞淋巴瘤研究进展 |
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| 引用本文： | 张凡. 伴有二次打击的弥漫大B细胞淋巴瘤研究进展[J]. 白血病．淋巴瘤, 2014, 23(2): 120-123 |
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| 作者姓名： | 张凡 |
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| 作者单位： | 张凡 (210019,南京明基医院血液内科)； |
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| 摘 要： | 弥漫大B细胞淋巴瘤（DLBCL）是一种异质性很大的非霍奇金淋巴瘤,其中同时伴有myc和bcl-2重排（或bcl-6重排）者是一种较少见的类型,被称作二次打击淋巴瘤.其临床表现为明显的侵袭性、对化疗耐药、预后极差,成为近年来研究的热点.文章探讨了伴有二次打击的DLBCL重排基因的功能、临床特征、诊断及治疗.
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| 关 键 词： | 二次打击淋巴瘤 淋巴瘤,大细胞,弥漫型 基因,myc 基因,bcl-2 基因,bcl-6 |
Research progress of double-hit diffuse large B-cell lymphoma |
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| Affiliation: | Zhang Fan, Li Dong. Department of Hematology, BENQ Hospital, Nanjing 210019, China |
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| Abstract: | Diffuse large B-cell lymphoma （DLBCL） is a heterogeneous group of non-Hodgkin＂ s lymphoma. An uncommon subset with myc and either bcl-2 or bcl-6 rearrangement, also known as ＇double-hit＇ lymphomas, is considered very aggressive clinical course and poor prognosis despite high-intensity chemotherapy. Recently, these lymphomas have received increased attention. This review explores the existing literatures for the involved genes with their functions, clinical features, diagnosis and treatment. |
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| Keywords: | Double-hit lymphoma Lymphoma, large-cell, diffuse Genes, myc Genes, bcl-2 Genes, bcl-6 |
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