Survivin 基因在大肠癌中的表达和临床意义

目的：探讨大肠癌组织凋亡抑制基因Survivin的表达和意义。方法：唐山市协和医院2009年1月至2013年10月具有完整临床和病理资料的大肠癌组织75例和正常大肠黏膜组织12例。应用免疫组织化学染色法检测Survivin蛋白的表达，并分析Survivin表达与大肠癌临床病理参数的关系。结果：大肠癌组织Survivin蛋白的阳性表达率为69.3%（52/75），明显高于大肠正常黏膜（P ＜0.01）。大肠癌组织Survivin 表达与年龄、性别、肿瘤部位无关（P ＞0.05）；与有无淋巴结转移、Dukes分期和分化程度有关（P ＜0.01，P ＜0.05）。结论：检测Survivin蛋白的表达水平对评估大肠癌的生物学行为具有重要价值；Survivin可为大肠癌的临床治疗提供新的分子靶向治疗位点。

EXPRESSION AND CLINICAL SIGNIFICANCE OF SURVIVIN IN COLORECTALCANCER

Objective：To investigate the expression and clinical significance of inhibitor of apoptosis gene Survivin in colorectal cancer. Methods： Immunohistochemical staining was used to detect the expression of Survivn protein in 75 cases colorectal cancer, which had complete clinical and pathological data in Tangshan Xiehe Hospital from 2009.1 to 2013.10, and then analyzed the relationships between Survivin expression and clinicopathological parameters of colorectal cancer. Results：The positive expresssion rate of Survivin protein in colorectal cancer was 69.3% （52/75）, which was obviously higher than that of normal colon mucosa （P〈0.01）. The expression of Survivin in colorectal cancer had no relations with age, sex and tumor location （P〉0.05）; but was related to lymph node metastasis, Dukes stage and differentiation degree （P〈0.01, P〈0.05）. Conclusions：It has important value to evaluate the biological behavior of colorectal cancer by detecting Survivin protein expression level, and Survivin can provide a new moleculartarget therapy sitefortreatingcolorectalcancer.