| 镉致肾脏损伤与锌代谢及其功能的关系 |
| |
| 引用本文： | 王智,胡斌丽,张豆豆,罗果,凌锌. 镉致肾脏损伤与锌代谢及其功能的关系[J]. 遵义医学院学报, 2008, 31(5) |
| |
| 作者姓名： | 王智 胡斌丽 张豆豆 罗果 凌锌 |
| |
| 作者单位： | 遵义医学院,贵州,遵义,56003 |
| |
| 基金项目： | 学生课外学术科技活动科研项目 |
| |
| 摘 要： | 目的探讨锌代谢的变化与镉肾损伤之间的关系。方法将12只清洁级大鼠随机分成染镉组和对照组,分别测定各组大鼠血、尿和肾组织中镉和锌含量,测定尿液中NAG活性、β2微球蛋白含量,测定肌酐以校正尿量。结果染镉组血、尿、肝组织和肾组织中镉含量升高;肾组织和血清锌含量有下降趋势,肝组织锌含量有升高趋势;尿液中NAG活性和β2微球蛋白含量升高;且染镉组血、尿、肝肾组织中镉含量均与尿液中NAG活性和β2微球蛋白含量呈正相关关系;而与肾组织锌含量呈负相关关系;肾组织锌含量与尿液中NAG活性、β2微球蛋白含量呈负相关关系;结论镉能影响大鼠体内锌分布改变,而锌分布改变与镉引起的肾脏损伤有关。
|
| 关 键 词： | 镉 锌 肾脏 N-乙酰-β-D-氨基葡萄糖苷酶 β_2微球蛋白 |
Relationship between renal eamage induced by cadmium and zinc metabolism and its functions in rats |
| |
| WANG Zhi,HU Bin-li,ZHANG Dou-dou et al. Relationship between renal eamage induced by cadmium and zinc metabolism and its functions in rats[J]. Acta Academiae Medicine Zunyi, 2008, 31(5) |
| |
| Authors: | WANG Zhi HU Bin-li ZHANG Dou-dou et al |
| |
| Affiliation: | WANG Zhi,HU Bin-li,ZHANG Dou-dou et al(Zunyi Medical College,Guizhou Zunyi 563003,China) |
| |
| Abstract: | Objective To explore relationship between the change of zinc metabolism and renal damage induced by cadmium.Methods Twelve rats were randomly divided into two groups:control group and cadmium injection group.The mixture of CdCl2 and mercaptoethanol(ME) was administered peritoneally to cadmium injection group.The contents of Cd and Zn in blood,urine,kidney and liver,and urinary N-acetyl-beta-D-glucosaminidase(UNAG) activity and β2-MG(Uβ2-MG)content were detected.Results Compared with the control group,the co... |
| |
| Keywords: | cadmium zinc kidney UNAG Uβ_2-MG |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
