血浆BNP水平在ST段抬高急性心肌梗死静脉溶栓中的临床意义

目的检测急性心肌梗死患者溶栓前后血浆BNF，探讨其变化特点及临床意义。方法60例患者分A组（未溶栓，18例），B组（溶栓未通，11例）和C组（溶栓冉通，31例），测定人院即刻，发病24小时和5天血浆BNP，进行组内和组间比较。结果三组发病24小时和5天BNP均高于入院即刻（P〈0．05），A及B组发病24小时和5天BNP比较差异无显著性（P〉0．05），C组发病5天BNP低于发病24小时（P〈0．05），三组入院即刻BNP比较差异无显著性（P〉0．05）．A和B组之间发病24小时以及5天的BNP比较差异无显著性（P〉0．05），但两组均相应高于C组（P〈0．05）。结论动态检测STEMI患者溶栓前后血浆BNP，有利于观察溶柃疗效、从而为病情评估、进一步治疗及预后判断提供依据。

The clinical significance of Serum BNP level before and after thrombolysis in the patients with ST-elevated myocardial infarction

Objective Brain natriuretic peptide (BNP) before and after thrombolysis in the patients with ST-elevated myocardial infarction(STEMI) were measured to explore their change characteristics and clinical significance.Methods 60 patients with a first ST -elevated myocardial infarction were divided into three groups :A group (non- thrombolysis n=18), B g-roup (non- reperfusion n=11) and C group (reperfusion n=31).the serum BNP at the hospitalized time,on24th hour and on the 5th day after ons-et of AMI wered measured with a immmunofluorescence assay provided by Triage Biosite, and then the consequences were compared between and in the groups. Results in the three groups :The levels of serum BN-P on the 24th hour and the 5th day were higher than those at the hos-pitalized time (P＜ 0.05), In the A and B groups,the serum BNP levels on the 5th day I were not different from those on 24th hour ,but in the -C group ,The levels of serum BNP on the 5th day were decreased sig-niticantly (P＜ 0.05) .between the groups: there are no diference in the the serum BNP levels at the hospitalized time.between the A and B grou-ps, the serum BNP levels both on the 24th hour and on the 5thday w-ere not diferent,but the serum BNP levels on the 24th hour and the 5th day of the two groups were higher than those of the reperfusion group(P＜ 0.05), Conclusion BNP measureme nt may help us evaluate the effi-cacy of thrombolysis,so it can offer evidence for assessing their condition, further treatment and the prognosis of AMI.