神经节苷脂联合复方丹参注射液治疗新生儿缺氧缺血性脑病的疗效观察

目的探讨神经节苷脂联合复方丹参注射液治疗新生儿缺氧缺血性脑病（HIE）的临床效果。方法选择2007年1月-2010年1月期间我院86例HIE患儿，并随机分为观察组43例和对照组43例，对照组给予常规三项支持、三项对症治疗。观察组则在对照组的基础上加用神经节苷脂联合复方丹参注射液。结果观察组总有效率为97．67％，对照组则为72．09％，两组相比差异有统计学意义（P〈0．05）。两组患儿治疗前NBNA评分无明显差异（P〉0．05），治疗5～7天和治疗10～14天NBNA评分有显著差异（尸〈0．05）。结论神经节苷脂联合复方丹参注射液治疗新生儿缺氧缺血性脑病。疗效显著，不但能有效地提高治愈率，还能有效地降低致砖率．

The efficacy of ganglioside combined with compound salvia miltiorrhiza injection for hypoxic-ischemic encephalopathy in neonates

Objective To explore the efficacy of ganglioside plus compound salvia miltiorrhiza injection for hypoxic-ischemic encephalopathy ( HIE )in neonates. Methods 86 neonates with HIE who had been hospitalized during January 2007 to January 2010 were randomly assgined to study group and control group ( 43 for each group ). The control group received three supporting therapies and symptomatic treatment and the study group received ganglioside plus compound salvia miltiorrhiza injection in addition to the therapies used in the control group. Results The total effectiveness rate was 97.67% in the study group and 72.09% in the control group, with a statistical significance ( P＜0.05 ). The NBNA scores did not differ significantly between the two groups before treatment ( P＞0.05 ), but differed significantly on days 5 to 7 and days 10 to 14 ( P＜ 0.05 ). Conclusions Ganglioside combined with compound miltiorrhiza salvia injection has a marked efficacy in the treatment of hypoxic-ischemic encephalopathy, not only raising the cure rate effectively, but also reducing the rate of disability effectively.