厚朴及姜厚朴乙酸乙酯提取部位对小鼠胃肠运动功能的影响

目的: 比较厚朴与姜厚朴乙酸乙酯提取部位对促进胃肠运动功能的药效. 方法: SPF级昆明种小鼠随机分为阴性(或模型)对照组、阳性药多潘立酮35 mg·kg^-1或雷尼替丁45.5 mg·kg^-1组和厚朴高、中、低剂量(0.678,0.452,0.226 g·kg^-1),姜厚朴高、中、低剂量(0.708,0.472,0.236 g·kg^-1)给药组,各组小鼠均连续ig 3 d,比较小肠推进率、盐酸性溃疡率、血清胃泌素含量. 结果: 厚朴和姜厚朴乙酸乙酯提取部位均能不同程度促进胃肠动力功能,在促进小肠推进率上,各给药组与阴性组有显著差异(P<0.05),与阳性药组无显著差异.在抑制溃疡上各给药组与模型组有显著差异(P<0.05).胃泌素含量厚朴低、中剂量与姜厚朴中剂量组血清胃泌素升高与阴性组存在显著差异(P<0.05). 结论: 姜厚朴与厚朴乙酸乙酯提取部位具有促进胃肠运动功能保护胃黏膜的作用,姜厚朴药效优于厚朴.

Effect of Ethyl Acetate Fractions in Magnolia officinalis and Ginger Magnolia officinalis on Gastrointestinal Motility Function in Mice

Objective: To compare the effect of ethyl acetate fractions in Magnolia officinalis and ginger M. officinalis on gastrointestinal motility function. Method: SPF Kunming mice were randomly divided into high, medium and low dose group, positive and negative control group. The dosage for mice was 1,2 and 3 times the highest M. officinalis for adult. After 3 days of administration, the effect of gastrointestinal motility function was evaluated by the intestinal propulsion rate, ulceration caused by hydrochloric acid and contents of the gastrin. Result: There was significant difference between test groups and negative contrast groups in the intestinal propulsion rate (P<0.05), and no significant difference between test groups and positive contrast groups. There was significant difference between test groups and negative contrast groups on inhibition of gastric ulcer (P<0.05). There were significant difference between medium dosage of ginger M. officinalis, low dosage of M. officinalis and negative contrast group on contents of the gastrin (P<0.05). There was no significant difference between medium dosage of ginger M. officinalis and positive contrast groups. Conclusion: The ethyl acetate fractions extracted from M. officinalis and ginger M. officinalis may promote gastrointestinal motility and protect gastric mucosa. The effect of ginger M. officinalis is better than that of M. officinalis.