Central opioid peptide-containing neurons mediates therapeutic effect of short-pulse gastric electrical stimulation on dyspepsia-like symptoms in dogs |
| |
Authors: | Bin Xu Xian Qiao Xiaoyun Yu Jingsong Liu |
| |
Institution: | Division of Gastroenterology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430022,China |
| |
Abstract: | This study investigated whether the curative effect of short-pulse gastric electrical stimulation (GES) on the vasopressin-induced
dyspeptic symptoms was mediated by central opioid peptide-producing neurons. Five female beagle dogs implanted with 1 pair
of electrodes in gastric serosa were used in a two-experiment study. In experiment one, the brain was scanned by positron
emission tomography in 3 dogs with and without short-pulse GES, and the radioactivity in nuclei of solitary tract (NST) and
hypothalamus was detected. Experiment two was composed of 4 sessions. In session one, the dogs were injected with vasopressin
in the absence of short-pulse GES. With session two, the short-pulse GES was simultaneously given via the electrodes with
the injection of vasopressin. In sessions three and four, naloxone and naloxone methiodide was administered respectively in
the presence of short-pulse GES. Motion sickness-like symptoms were scored and compared among the different sessions. The
results showed that the short-pulse GES significantly increased the radioactivity in NST and hypothalamic nuclei (P<0.05, vs control). The short-pulse GES could ameliorate the vasopressin-induced motion sickness-like symptoms in dogs. Naloxone,
but not naloxone methiodide could attenuate the curative effects of short-pulse GES. It is concluded that NST and hypothalamic
nuclei may participate in the mediation of the curative effects of short-pulse GES on dyspepsia-like symptoms. Central opioid
peptide-containing neurons presumably mediate the therapeutic effect on dyspeptic symptoms of short-pulse GES. |
| |
Keywords: | short-pulse gastric electrical stimulation dyspeptic symptoms opioid peptide-containing neurons |
本文献已被 维普 万方数据 SpringerLink 等数据库收录! |
|