银虎汤治疗进行期寻常型银屑病临床及实验研究

目的观察银虎汤治疗进行期寻常性银屑病的临床疗效及其对血清IL-8的影响。方法选取进行期寻常性银屑病患者78例，随机分为治疗组45例和对照组33例，分别采用银虎汤和复方青黛胶囊，并选取健康志愿者12例为正常组，观察治疗组和对照组及正常组血清IL-8水平，治疗组和对照组临床疗效、PASI值及治疗前后血清IL-8水平比较。结果进行期寻常性银屑病患者血清IL-8水平高于正常对照组（P〈0．01），治疗组和对照组临床总有效率分别为91．11％、72．73％，对比有显著差别（P〈0．05），治疗前后治疗组血清IL-8水平明显下降（P〈0．01），PASI值明显下降（P〈．01）。结论银虎汤治疗进行期寻常性银屑病疗效确切，可阵低PASI值和血清IL-8水平。

Clinial and Experimental Study on Progressive Psoriasis Vulgaris Treated by Yinhu Decoction

Objective: To investigate the clinical effect of Yinhu decoction treating progressing psoriasis vulgaris (PVP) patients , objectively evaluate the serum level of IL-8 in PVP and the effect of Yinhu decoction. Methods: 78 PVP patients were randomly divided into treated group (n=45) and control group (n=33), they were treated with Yinhu decoction and compound Qingdai capsule respectively. 12 healthy persons subjects were selected as normal control. The serum level of IL-8 in all patients and healthy person subject as well as clinical therapeutical effect of the treatment and the psoriasis area and severity index (PASI) were observed and compared Results: The 8 weeks' total effective rate in treated group and control group were 91. 11% and 72. 73% respectively. Comparison between them showed significant difference (P<0. 05). Serum level of IL-8 in the patients before treatment were higher than that in healthy subjects (P<0. 01) ;after 8 weeks'treatment, it lowered significantly in the treated group (P<0. 05). The PASI were lowered (P<0. 01). Conclusion: Yinhu decoction has certain clinical effect in treating PVP, it could lower PASI and the serum level of IL-8.