99Tc-HL91乏氧显像评价30例鼻咽癌患者放疗疗效

目的 探讨99mTc-4,9-二氮杂-3,3,10,10-四甲基十二烷-2,11-二酮二肟(99Tc-HL91)乏氧显像评价鼻咽癌放疗疗效的临床价值.方法 鼻咽癌患者30例,放疗前经肘静脉注射99mTc-HL91 1110 MBq后1h、4h,分别进行头颈部SPECT,用感兴趣区技术求出肿瘤组织/头皮本底(T/B)比值,放疗结束后4周按WHO标准进行放疗疗效评价.结果 ①30例鼻咽癌患者99mTc-HL91显像1h和4h的T/B比值均值分别为1.370±0.207和1.883±0.358,具有统计学差异(t=6.794,P＜0.001).②放疗有效组与无效组的1h和4h T/B比值均值分别为1.273±0.196与1.498±0.147和1.679±0.232与2.152±0.318,也具有统计学差异.结论 99mTc-HL91显像可探测鼻咽癌病灶乏氧状态,在预测放疗疗效方面有一定的应用价值.

The application of 99mTc-HL91 hypoxic imaging in detecting radiotherapy response in 30 patients with nasopharyngeal carcinoma

Objective To investigate the clinical value of 99mTc-4,9-diaza-3,3,10,10-tetramethyldodecan-2,11-dione dioxime(99mTc-HL91)hypoxia imaging in detecting radiotherapy response of nasopharyngeal carcinoma.Methods Thirty patients with nasopharyngeal carcinoma who will receive radiotherapy underwent 99mTc-HL91 imaging at 1h and 4h post-injection of 99mTc-HL91.Region of interest technique was used to calculate the tumor-to-background ratios of scalp(T/B).The effects of radiotherapy HL91 uptake ratios of T/B in thirty patients at 1h and 4h imaging were 1.370±0.207 and 1.883±0.358.The follow-up results demonstrated that the average T/B value at 1h and 4h phase in the group of effective radiotherapy and ineff ective radiotherapy were 1.273±0.196 and 1.498±0.147.1.679±0.232 and 2.152±0.318,respectively.There was a significant difference between T/B value of the two group.Conclusion The hypoxia status can be observed by 99mTc-HL91 imaging which has certain clinical value in forecasting the effects of radiotherapy.